ArticleThe Journal of investigative dermatology2013
Rejuvenation of gene expression pattern of aged human skin by broadband light treatment: a pilot study.
Article in The Journal of investigative dermatology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. It is linked to trial NCT03690375 (A Prospective, Randomized, Split-Arm Pilot Study Investigating the Efficacy and Safety of Sciton's Broad Band Light for Improving the Clinical Signs of Senile Purpura), which is not on this map. Cited by 16 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Prospective, Randomized, Split-Arm Pilot Study Investigating the Efficacy and Safety of Sciton's Broad Band Light for Improving the Clinical Signs of Senile Purpura
Who cites it
16 citing papers in PubMed, 56 citations in OpenAlex.
- Real-World Broadband Light Treatment Strategies and Early Treatment Response in Facial Vascular Lesions: A Retrospective Observational Study.Dermatology and therapy · 2026Article
- Evolution of Facial Assessment in Aesthetic Medicine: 3D Imaging, Digital Analysis, and Patient-Reported Outcomes.Aesthetic plastic surgery · 2026Review
- Non-ablative fractional laser 1940-nm treatment modulates epigenetic signatures associated with skin aging in a split-face investigation.Scientific reports · 2026Article
- Energy-Based Devices for GLP-1 Receptor Agonist-Associated Facial Aging: A Tissue-Specific Safety Framework.Clinical, cosmetic and investigational dermatology · 2026Review
- Advances in the application of multi-omics analysis in skin aging.Frontiers in aging · 2025Review
- Effects of Age and Sex on the Expression of Core Circadian Clock Genes in Human Skin Epidermis.The Journal of investigative dermatology · 2024Article
- Modulation of the ubiquitin-proteasome system by marine natural products.Redox biology · 2021Review
- Article
- Epidermal Stem Cells in Wound Healing and Regeneration.Stem cells international · 2020Review
- The RNA world of human ageing.Human genetics · 2018Review
- Aging-Associated Decline of Epidermal PSMD8 Contributes to Impaired Skin Function.The Journal of investigative dermatology · 2018Article
- Novel Gene Expression Profile of Women with Intrinsic Skin Youthfulness by Whole Transcriptome Sequencing.PloS one · 2016Article
- Intense pulsed light induces synthesis of dermal extracellular proteins in vitro.Lasers in medical science · 2015Article
- Genetics and epigenetics of aging and longevity.Cell cycle (Georgetown, Tex.) · 2014Review
- A mammalian pseudogene lncRNA at the interface of inflammation and anti-inflammatory therapeutics.eLife · 2013Article
- All's well that ends well: alternative polyadenylation and its implications for stem cell biology.Current opinion in cell biology · 2013Review
Corrections and comments
- Erratum issued
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
Abstract
Studies in model organisms suggest that aged cells can be functionally rejuvenated, but whether this concept applies to human skin is unclear. Here we apply 3'-end sequencing for expression quantification ("3-seq") to discover the gene expression program associated with human photoaging and intrinsic skin aging (collectively termed "skin aging"), and the impact of broadband light (BBL) treatment. We find that skin aging was associated with a significantly altered expression level of 2,265 coding and noncoding RNAs, of which 1,293 became "rejuvenated" after BBL treatment; i.e., they became more similar to their expression level in youthful skin. Rejuvenated genes (RGs) included several known key regulators of organismal longevity and their proximal long noncoding RNAs. Skin aging is not associated with systematic changes in 3'-end mRNA processing. Hence, BBL treatment can restore gene expression pattern of photoaged and intrinsically aged human skin to resemble young skin. In addition, our data reveal, to our knowledge, a previously unreported set of targets that may lead to new insights into the human skin aging process.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.