ReviewCurrent opinion in otolaryngology & head and neck surgery2012
Tinnitus and underlying brain mechanisms.
Review in Current opinion in otolaryngology & head and neck surgery, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06718452 (Treatment of Tinnitus Targeting Neuroinflammation. umPEALUT as Possible Option), which is not on this map. Cited by 33 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Treatment of Tinnitus Targeting Neuroinflammation. umPEALUT as Possible Option
Who cites it
33 citing papers in PubMed, 1 synthesis or guideline pooled it, 71 citations in OpenAlex.
- A multidisciplinary systematic review of the treatment for chronic idiopathic tinnitus.European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery · 2017Pooled it
- Musical auditory training and cognitive auditory training: effects on the perception of tinnitus disorder.CoDAS · 2026Trial
- A clinical trial of a patient-customized virtual reality intervention for tinnitus.Scientific reports · 2022Trial
- The Auditory-Visual Stroop Test to Assess Subjects with Tinnitus.Brain sciences · 2026Article
- Noise-Induced Hearing Loss Enhances CaThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- An Insight into Role of Auditory Brainstem in Tinnitus: A Systematic Review of Diagnostic Assessments.Audiology research · 2025Review
- Bidirectional Associations Between Tinnitus Subtypes and Psychiatric Conditions.The Laryngoscope · 2025Article
- Improvement of Chronic Tinnitus Following Personalized, Parcel-guided Accelerated rTMS: Feasibility in a Retrospective Case Series.Brain topography · 2025Article
- Fasting Glucose, Haemoglobin A1C (HbA1c), Blood Lipid, and Triglyceride-Glucose Index Parameters in Relation to Subjective Tinnitus.Biomedicines · 2025Article
- Exploring P300 Responses in Tinnitus: Linking Cognitive and Audiological Assessments.Indian journal of otolaryngology and head and neck surgery : official publication of the Association of Otolaryngologists of India · 2025Article
- Frailty links the heterogeneity of tinnitus disorder and response to interventions in older patients.Frontiers in neurology · 2025Review
- The results of short-course acoustic test could act as an effective predictor of the efficacy of customized music therapy for chronic tinnitus.Frontiers in neuroscience · 2025Article
- Cross-Modal Tinnitus Remediation: A Tentative Theoretical Framework.Brain sciences · 2024Article
- Comparative study on structural and functional brain differences in mild cognitive impairment patients with tinnitus.Frontiers in aging neuroscience · 2024Article
- Acupuncture for Tinnitus: A Scoping Review of Clinical Studies.Complementary medicine research · 2024Article
- Combining unequal variance signal detection theory with the health belief model to optimize shared decision making in tinnitus patients: part 1-model development.Frontiers in neuroscience · 2024Article
- Psychological Impact and Quality of Life in Adults With Tinnitus: A Cross-Sectional Study.Cureus · 2024Article
- Article
- Depolarization shift in the resting membrane potential of inferior colliculus neurons explains their hyperactivity induced by an acoustic trauma.Frontiers in neuroscience · 2023Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 3 institutions in 1 country.
Funding
Abstract
purpose of reviewTinnitus is the sensation of hearing a sound when no external auditory stimulus is present. Most individuals experience tinnitus for brief, unobtrusive periods. However, chronic sensation of tinnitus affects approximately 17% (44 million people) of the general US population. Tinnitus, usually a benign symptom, can be constant, loud and annoying to the point that it causes significant emotional distress, poor sleep, less efficient activities of daily living, anxiety, depression and suicidal ideation/attempts. Tinnitus remains a major challenge to physicians because its pathophysiology is poorly understood and there are few management options to offer to patients. The purpose of this article is to describe the current understanding of central neural mechanisms in tinnitus and to summarize recent developments in clinical approaches to tinnitus patients. RECENT
findingsRecently developed animal models of tinnitus provide the possibility to determine neuronal mechanisms of tinnitus generation and to test the effects of various treatments. The latest research using animal models has identified a number of abnormal changes, in both auditory and nonauditory brain regions, that underlie tinnitus. Furthermore this research sheds light on cellular mechanisms that are responsible for development of these abnormal changes. SUMMARY: Tinnitus remains a challenging disorder for patients, physicians, audiologists and scientists studying tinnitus-related brain changes. This article reviews recent findings of brain changes in animal models associated with tinnitus and a brief review of clinical approach to tinnitus patients.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.