ArticleBMC medicine2012
Intracranial hemorrhage in adult patients with hematological malignancies.
Article in BMC medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 1 of them a synthesis that pooled it.
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Who cites it
22 citing papers in PubMed, 1 synthesis or guideline pooled it, 79 citations in OpenAlex.
- Predictive Performance of HAS-BLED Score in Patients with Atrial Fibrillation and Cancer: A Meta-Analysis.Cardiology · 2025Pooled it
- Cathepsin G is associated with cerebral vascular injury in myeloid leukemia: a pathologic insight into intracranial hemorrhage.Research and practice in thrombosis and haemostasis · 2026Article
- Decision-making for emergency craniotomy in traumatic intracranial hemorrhage with severe thrombocytopenia and coagulopathy in a patient with suspected acute leukemia: A case-based review.Surgical neurology international · 2026Article
- Diagnostic Challenges in Acute Leukemia: From Dental Pain to Catastrophic Intracerebral Hemorrhage.Hematology reports · 2025Article
- Management of thrombocytopenia and anticoagulant therapy in patients with hematological malignancy on chemotherapy: a binational prospective study (TAT study).Journal of thrombosis and thrombolysis · 2025Article
- Middle Meningeal Artery Embolization in Acute Leukemia Patients Presenting With Subdural Hematoma.Journal of hematology · 2024Article
- Global hemostasis assays in acute myeloid leukemia: results of an observational prospective study.Blood transfusion = Trasfusione del sangue · 2024Observational
- Malignant solid tumor-related spontaneous intracerebral hemorrhage: a propensity score matching study.PeerJ · 2024Article
- Treatment of acute ischemic stroke in patients with active malignancy: insight from a comprehensive stroke center.Therapeutic advances in neurological disorders · 2023Article
- Leukemic retinopathy presenting as concurrent bilateral subhyaloid hemorrhage and subarachnoid hemorrhage in a patient with acute monocytic leukemia: a case report.Journal of medical case reports · 2022Article
- Clinical characteristics and prognostic factors in intracranial hemorrhage patients with hematological diseases.Annals of hematology · 2022Article
- Intraparenchymal Hemorrhage: A Fatal Presentation of Undiagnosed Acute Myelogenous Leukemia.Cureus · 2022Article
- Predicting mortality from intracranial hemorrhage in patients who undergo allogeneic hematopoietic stem cell transplantation.Blood advances · 2021Article
- Thrombocytopenia and the effect of platelet transfusions on the occurrence of intracranial hemorrhage in patients with acute leukemia - a nested case-control study.Annals of hematology · 2021Article
- Intracranial Hemorrhage in Hospitalized Patients: An Infrequently Studied Condition with High Mortality.Neurocritical care · 2020Article
- Comparison of hemorrhagic and ischemic stroke after allogeneic hematopoietic stem cell transplantation.Bone marrow transplantation · 2020Article
- Cardiovascular Diseases And Psychiatric Disorders During The Diagnostic Workup Of Suspected Hematological Malignancy.Clinical epidemiology · 2019Article
- New onset acute promyelocytic Leukemia during pregnancy: report of 2 cases.Cancer biology & therapy · 2019Article
- Therapeutic Anticoagulation in Patients with Primary Brain Tumors or Secondary Brain Metastasis.The oncologist · 2018Review
- Spontaneous intracranial haemorrhage in critically ill patients with malignancies.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2016Article
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11 authors at 2 institutions in 1 country.
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Abstract
backgroundClinical characteristics and outcomes of intracranial hemorrhage (ICH) among adult patients with various hematological malignancies are limited.
methodsA total of 2,574 adult patients diagnosed with hematological malignancies admitted to a single university hospital were enrolled into this study between 2001 and 2010. The clinical characteristics, image reports and outcomes were retrospectively analyzed.
resultsA total of 72 patients (48 men and 24 women) with a median age of 56 (range 18 to 86) had an ICH. The overall ICH incidence was 2.8% among adult patients with hematological malignancies. The incidence of ICH was higher in acute myeloid leukemia (AML) patients than in patients with other hematological malignancies (6.3% vs 1.1%, P = 0.001). ICH was more common among patients with central nervous system (CNS) involvement of lymphoma than among patients with CNS involved acute leukemia (P <0.001). Sites of ICH occurrence included the cerebral cortex (60 patients, 83%), basal ganglia (13 patients, 18%), cerebellum (10 patients, 14%), and brainstem (5 patients, 7%). A total of 33 patients (46%) had multifocal hemorrhages. In all, 56 patients (77%) had intraparenchymal hemorrhage, 22 patients (31%) had subdural hemorrhage, 15 patients (21%) had subarachnoid hemorrhage (SAH), and 3 patients (4%) had epidural hemorrhage. A total of 22 patients had 2 or more types of ICH. In all, 46 (64%) patients died of ICH within 30 days of diagnosis, irrespective of the type of hematological malignancy. Multivariate analysis revealed three independent prognostic factors: prolonged prothrombin time (P = 0.008), SAH (P = 0.021), and multifocal cerebral hemorrhage (P = 0.026).
conclusionsThe incidence of ICH in patients with AML is higher than patients with other hematological malignancies. But in those with intracranial malignant disease, patients with CNS involved lymphoma were more prone to ICH than patients with CNS involved acute leukemia. Mortality was similar regardless of the type of hematological malignancy. Neuroimaging studies of the location and type of ICH could assist with prognosis prediction for patients with hematological malignancies.
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