ArticleMolecular microbiology2012
Interspecies modulation of bacterial development through iron competition and siderophore piracy.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 91 papers.
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Who cites it
91 citing papers in PubMed.
- A widespread actinobacterial G protein system regulates production of specialized metabolites inmSphere · 2026Article
- Article
- Multi-omics analysis of interspecies interactions in a soil Streptomyces community provides functional insights into siderophore ecology.Scientific reports · 2026Article
- Antagonistic Mechanisms of Probiotic Aliivibrio sp. Strain Vl2 Against Moritella viscosa: Evidence from Co-cultivation and Targeted Transcriptomic Analysis.Probiotics and antimicrobial proteins · 2026Article
- A quorum-sensing molecule fromProceedings of the National Academy of Sciences of the United States of America · 2026Article
- Lactuchelins represent lipopeptide siderophores produced by Pseudomonas lactucae that inhibit Xanthomonas campestris.The ISME journal · 2026Article
- Article
- Why Do FilamentousAnnual review of microbiology · 2025Review
- Genomic and Metabolomic Insights into the Antimicrobial Activities and Plant-Promoting Potential ofMicroorganisms · 2025Article
- Genetic and biochemical insights into siderophore biosynthesis in the marine fish pathogen Tenacibaculum maritimum.Scientific reports · 2025Article
- The accessory protein CvnF8 modulates histidine kinase activity in an Actinobacterial G protein system inbioRxiv : the preprint server for biology · 2025Article
- Chemical Conversations.Molecules (Basel, Switzerland) · 2025Review
- Bioactive exometabolites drive maintenance competition in simple bacterial communities.mSystems · 2024Article
- Article
- MOB rules: Antibiotic Exposure Reprograms Metabolism to MobilizebioRxiv : the preprint server for biology · 2024Article
- Nasal commensals reduce Staphylococcus aureus proliferation by restricting siderophore availability.The ISME journal · 2024Article
- Proximity-based defensive mutualism between Streptomyces and Mesorhizobium by sharing and sequestering iron.The ISME journal · 2024Article
- Interactions of DifferentInternational journal of molecular sciences · 2023Article
- Community composition drives siderophore dynamics in multispecies bacterial communities.BMC ecology and evolution · 2023Article
- Iron acquisition strategies in pseudomonads: mechanisms, ecology, and evolution.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2023Review
31 more citing papers are in PubMed but not listed here.
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Authors and funding
4 authors.
Funding
Abstract
While soil-dwelling actinomycetes are renowned for secreting natural products, little is known about the roles of these molecules in mediating actinomycete interactions. In a previous co-culture screen, we found that one actinomycete, Amycolatopsis sp. AA4, inhibited aerial hyphae formation in adjacent colonies of Streptomyces coelicolor. A siderophore, amychelin, mediated this developmental arrest. Here we present genetic evidence that confirms the role of the amc locus in the production of amychelin and in the inhibition of S. coelicolor development. We further characterize the Amycolatopsis sp. AA4 - S. coelicolor interaction by examining expression of developmental and iron acquisition genes over time in co-culture. Manipulation of iron availability and/or growth near Amycolatopsis sp. AA4 led to alterations in expression of the critical developmental gene bldN, and other key downstream genes in the S. coelicolor transcriptional cascade. In Amycolatopsis sp. AA4, siderophore genes were downregulated when grown near S. coelicolor, leading us to find that deferrioxamine E, produced by S. coelicolor, could be readily utilized by Amycolatopsis sp. AA4. Collectively these results suggest that competition for iron via siderophore piracy and species-specific siderophores can alter patterns of gene expression and morphological differentiation during actinomycete interactions.
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