ArticleMolecular microbiology2012
Changes in the oligomerization potential of the division inhibitor UgtP co-ordinate Bacillus subtilis cell size with nutrient availability.
Article in Molecular microbiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed.
- The phosphoenolpyruvate phosphotransferase system regulates cell length and width through semi-independent pathways.Molecular biology of the cell · 2026Article
- Metabolic engineering ofSynthetic and systems biotechnology · 2025Article
- Queuosine biosynthetic enzyme, QueE moonlights as a cell division regulator.PLoS genetics · 2024Article
- Cellular resource allocation strategies for cell size and shape control in bacteria.The FEBS journal · 2022Review
- Bacterial cell shape control by nutrient-dependent synthesis of cell division inhibitors.Biophysical journal · 2021Article
- Article
- Metabolic Control of Cell Elongation and Cell Division inFrontiers in microbiology · 2021Review
- Disruption of the MreB Elongasome Is Overcome by Mutations in the Tricarboxylic Acid Cycle.Frontiers in microbiology · 2021Article
- The Inorganic Nutrient Regime and themSphere · 2020Article
- Cell morphology maintenance in Bacillus subtilis through balanced peptidoglycan synthesis and hydrolysis.Scientific reports · 2020Article
- The length of lipoteichoic acid polymers controlsJournal of bacteriology · 2020Article
- Fundamental principles in bacterial physiology-history, recent progress, and the future with focus on cell size control: a review.Reports on progress in physics. Physical Society (Great Britain) · 2018Review
- A nutrient-dependent division antagonist is regulated post-translationally by the Clp proteases in Bacillus subtilis.BMC microbiology · 2018Article
- Bacterial Cell Size: Multifactorial and Multifaceted.Annual review of microbiology · 2017Review
- YvcK, a protein required for cell wall integrity and optimal carbon source utilization, binds uridine diphosphate-sugars.Scientific reports · 2017Article
- Osmoregulated Periplasmic Glucans.EcoSal Plus · 2017Article
- Metabolism Shapes the Cell.Journal of bacteriology · 2017Review
- Effect of Cell Aspect Ratio on Swarming Bacteria.Physical review letters · 2017Article
- Article
- The Composition of the Cell Envelope Affects Conjugation in Bacillus subtilis.Journal of bacteriology · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
How cells co-ordinate size with growth and development is a major, unresolved question in cell biology. In previous work we identified the glucosyltransferase UgtP as a division inhibitor responsible for increasing the size of Bacillus subtilis cells under nutrient-rich conditions. In nutrient-rich medium, UgtP is distributed more or less uniformly throughout the cytoplasm and concentrated at the cell poles and/or the cytokinetic ring. Under these conditions, UgtP interacts directly with FtsZ to inhibit division and increase cell size. Conversely, under nutrient-poor conditions, UgtP is sequestered away from FtsZ in punctate foci, and division proceeds unimpeded resulting in a reduction in average cell size. Here we report that nutrient-dependent changes in UgtP's oligomerization potential serve as a molecular rheostat to precisely co-ordinate B. subtilis cell size with nutrient availability. Our data indicate UgtP interacts with itself and the essential cell division protein FtsZ in a high-affinity manner influenced in part by UDP glucose, an intracellular proxy for nutrient availability. These findings support a model in which UDP-glc-dependent changes in UgtP's oligomerization potential shift the equilibrium between UgtP•UgtP and UgtP•FtsZ, fine-tuning the amount of FtsZ available for assembly into the cytokinetic ring and with it cell size.
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