ArticleProceedings of the National Academy of Sciences of the United States of America2012
Antibodies and IL-3 support helminth-induced basophil expansion.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
27 citing papers in PubMed, 46 citations in OpenAlex.
- Article
- Modulation of haematopoiesis by protozoal and helminth parasites.Parasite immunology · 2023Review
- IL-3 Expands Pre-Basophil and Mast Cell Progenitors by Upregulating the IL-3 Receptor Expression.Cellular immunology · 2022Article
- Trickle infection withFrontiers in immunology · 2022Article
- Basophils as a potential therapeutic target in cancer.Journal of Zhejiang University. Science. B · 2021Review
- Diverse innate stimuli activate basophils through pathways involving Syk and IκB kinases.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Basophils in antihelminth immunity.Seminars in immunology · 2021Review
- BHLHE40 Promotes TJournal of immunology (Baltimore, Md. : 1950) · 2020Article
- Basophils and Eosinophils in Nematode Infections.Frontiers in immunology · 2020Review
- Intestinal helminth infection promotes IL-5- and CD4Mucosal immunology · 2019Article
- The Basoph8 Mice Enable an Unbiased Detection and a Conditional Depletion of Basophils.Frontiers in immunology · 2019Article
- The role of rare innate immune cells in Type 2 immune activation against parasitic helminths.Parasitology · 2017Review
- Negative Regulation of Type 2 Immunity.Trends in immunology · 2017Review
- Immune polarization by hookworms: taking cues from T helper type 2, type 2 innate lymphoid cells and alternatively activated macrophages.Immunology · 2016Review
- Innate cell communication kick-starts pathogen-specific immunity.Nature immunology · 2016Review
- The Evolution of Human Basophil Biology from Neglect towards Understanding of Their Immune Functions.BioMed research international · 2016Review
- IL-3 contributes to development of lupus nephritis in MRL/lpr mice.Kidney international · 2015Article
- Immune antibodies and helminth products drive CXCR2-dependent macrophage-myofibroblast crosstalk to promote intestinal repair.PLoS pathogens · 2015Article
- Antibody-mediated trapping of helminth larvae requires CD11b and Fcγ receptor I.Journal of immunology (Baltimore, Md. : 1950) · 2015Article
- Basophil-mediated protection against gastrointestinal helminths requires IgE-induced cytokine secretion.Proceedings of the National Academy of Sciences of the United States of America · 2014Article
Corrections and comments
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Authors and funding
15 authors at 6 institutions in 4 countries.
Funding
Abstract
Basophils are powerful mediators of Th2 immunity and are present in increased numbers during allergic inflammation and helminth infection. Despite their ability to potentiate Th2 immunity the mechanisms regulating basophil development remain largely unknown. We have found a unique role for isotype-switched antibodies in promoting helminth-induced basophil production following infection of mice with Heligmosomoides polygyrus bakeri or Nippostrongylus brasiliensis. H. polygyrus bakeri-induced basophil expansion was found to occur within the bone marrow, and to a lesser extent the spleen, and was IL-3 dependent. IL-3 was largely produced by CD4(+)CD49b(+)NK1.1(-) effector T cells at these sites, and required the IL-4Rα chain. However, antibody-deficient mice exhibited defective basophil mobilization despite intact T-cell IL-3 production, and supplementation of mice with immune serum could promote basophilia independently of required IL-4Rα signaling. Helminth-induced eosinophilia was not affected by the deficiency in isotype-switched antibodies, suggesting a direct effect on basophils rather than through priming of Th2 responses. Although normal type 2 immunity occurred in the basopenic mice following primary infection with H. polygyrus bakeri, parasite rejection following challenge infection was impaired. These data reveal a role for isotype-switched antibodies in promoting basophil expansion and effector function following helminth infection.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.