ArticleJournal of neurology, neurosurgery, and psychiatry2012
Is psycho-physical stress a risk factor for stroke? A case-control study.
Article in Journal of neurology, neurosurgery, and psychiatry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 5 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 5 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Psychosocial stress and risk of first-ever stroke: a systematic review and meta-analysis.BMC neurology · 2026Pooled it
- The correlation between perceived psychosocial stress and stroke: a meta-analysis.Frontiers in neurology · 2025Pooled it
- Psychosocial stress and stroke risk: meta-analysis of observational studies.Frontiers in neurology · 2025Pooled it
- Developing a synthetic psychosocial stress measure and harmonizing CVD-risk data: a way forward to GxE meta- and mega-analyses.BMC research notes · 2018Pooled it
- Evidence of perceived psychosocial stress as a risk factor for stroke in adults: a meta-analysis.BMC neurology · 2015Pooled it
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- Stroke risk and its association with quality of life: a cross-sectional study among Chinese urban adults.Health and quality of life outcomes · 2021Article
- Trajectories of family and employment stress associated with cerebrovascular accidents.Revista de saude publica · 2021Article
- Women's heart health at mid-life: what is the role of psychosocial stress?Women's midlife health · 2018Review
- The Association Between Peptic Ulcer Disease and Ischemic Stroke: A Population-Based Longitudinal Study.Medicine · 2016Observational
- Life Psychosocial Stresses and Coronary Artery Disease.International journal of preventive medicine · 2016Article
- Stress resilience in male adolescents and subsequent stroke risk: cohort study.Journal of neurology, neurosurgery, and psychiatry · 2014Article
- Migraine and stroke: "vascular" comorbidity.Frontiers in neurology · 2014Review
- The immune system in stroke: clinical challenges and their translation to experimental research.Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology · 2013Review
- A conversion disorder or a stroke? A proximal basilar artery thrombosis induced 'locked-in' syndrome in a young Caucasian woman.BMJ case reports · 2013Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundChronic stress is associated with cardiovascular diseases, but the link with stroke has not been well established. Stress is influenced by life-style habits, personality type and anxiety levels. We sought to evaluate psycho-physical stress as a risk factor for stroke, while assessing gender influences.
methodsCase-control study. cases: patients (n=150) aged 18-65, admitted consecutively to our Stroke Unit with the diagnosis of incident stroke. CONTROLS: (n=300) neighbours (paired with case ±5 years) recruited from the census registry. STUDY VARIABLES: socio-demographic characteristics, vascular risk factors, psychophysical scales of H&R (Holmes & Rahe questionnaire of life events), ERCTA (recall scale of type A behaviour), SF12 (QoL scale), GHQ28 (general health questionnaire). Statistical analyses included conditional multiple logistic regression models.
resultsMean age was 53.8 years (SD: 9.3). Compared with controls, and following adjustment for confounding variables, significant associations between stroke and stress were: H&R values >150 OR=3.84 (95% CI 1.91 to 7.70, p<0.001); ERCTA (values >24) OR=2.23 (95% CI 1.19 to 4.18, p=0.012); mental SF12 (values >50) OR=0.73 (95% CI 0.39 to 1.37, p=0.330); psychological SF12 (values >50) OR=0.66 (95% CI 0.33 to 1.30, p=0.229), male gender OR=9.33 (95% CI 4.53 to 19.22, p<0.001), high consumption of energy-providing beverages OR=2.63 (95% CI 1.30 to 5.31, p=0.007), current smoker OR=2.08 (95% CI 1.01 to 4.27, p=0.046), ex-smoker OR=2.35 (95% CI 1.07 to 5.12, p=0.032), cardiac arrhythmia OR=3.18 (95% CI 1.19 to 8.51, p=0.022) and Epworth scale (≥9) OR=2.83 (95% CI 1.03 to 7.78, p=0.044).
conclusionsCompared with healthy age-matched individuals, stressful habits and type A behaviour are associated with high risk of stroke. This association is not modified by gender.
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