ArticlePhysiological genomics2012
Quantitative proteomic analysis reveals novel mitochondrial targets of estrogen deficiency in the aged female rat heart.
Article in Physiological genomics, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Estrogen Degradation Metabolites: Some Effects on Heart Mitochondria.Journal of xenobiotics · 2025Article
- Central and Peripheral Inflammation: A Common Factor Causing Addictive and Neurological Disorders and Aging-Related Pathologies.International journal of molecular sciences · 2023Review
- Sex Steroid Receptors in Polycystic Ovary Syndrome and Endometriosis: Insights from Laboratory Studies to Clinical Trials.Biomedicines · 2022Review
- Sex Differences in Molecular Mechanisms of Cardiovascular Aging.Frontiers in aging · 2021Review
- Mitochondria in Sex Hormone-Induced Disorder of Energy Metabolism in Males and Females.Frontiers in endocrinology · 2021Review
- Sex Differences in Cardiovascular Aging and Heart Failure.Current heart failure reports · 2020Review
- Plasma proteomic changes during therapeutic hypothermia in resuscitated patients after cardiac arrest.Experimental and therapeutic medicine · 2019Article
- Estrogens, Estrogen Receptors Effects on Cardiac and Skeletal Muscle Mitochondria.Frontiers in endocrinology · 2019Review
- The Role of 17β-Estradiol and Estrogen Receptors in Regulation of CaFrontiers in endocrinology · 2019Review
- Inhibition of programmed necrosis limits infarct size through altered mitochondrial and immune responses in the aged female rat heart.American journal of physiology. Heart and circulatory physiology · 2018Article
- Age and ischemia differentially impact mitochondrial ultrastructure and function in a novel model of age-associated estrogen deficiency in the female rat heart.Pflugers Archiv : European journal of physiology · 2017Article
- Evidence of Altered Mitochondrial Protein Expression After Chronic Ethanol Consumption in the Aged Estrogen-Deficient Female Rat Heart.Alcoholism, clinical and experimental research · 2017Article
- Mitochondria and ageing: role in heart, skeletal muscle and adipose tissue.Journal of cachexia, sarcopenia and muscle · 2017Review
- Estrogen receptor alpha activation enhances mitochondrial function and systemic metabolism in high-fat-fed ovariectomized mice.Physiological reports · 2016Article
- Resveratrol attenuated estrogen-deficient-induced cardiac dysfunction: role of AMPK, SIRT1, and mitochondrial function.American journal of translational research · 2016Article
- Estrogen: an emerging regulator of insulin action and mitochondrial function.Journal of diabetes research · 2015Review
- Plasma proteomic changes during hypothermic and normothermic cardiopulmonary bypass in aortic surgeries.International journal of molecular medicine · 2014Article
- Quantitative proteomics in cardiovascular research: global and targeted strategies.Proteomics. Clinical applications · 2014Review
- Estrogen and the female heart.Molecular and cellular endocrinology · 2014Review
- Low abundance of the matrix arm of complex I in mitochondria predicts longevity in mice.Nature communications · 2014Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The incidence of myocardial infarction rises sharply at menopause, implicating a potential role for estrogen (E(2)) loss in age-related increases in ischemic injury. We aimed to identify quantitative changes to the cardiac mitochondrial proteome of aging females, based on the hypothesis that E(2) deficiency exacerbates age-dependent disruptions in mitochondrial proteins. Mitochondria isolated from left ventricles of adult (6 mo) and aged (24 mo) F344 ovary-intact or ovariectomized (OVX) rats were labeled with 8plex isobaric tags for relative and absolute quantification (iTRAQ; n = 5-6/group). Groups studied were adult, adult OVX, aged, and aged OVX. In vivo coronary artery ligation and in vitro mitochondrial respiration studies were also performed in a subset of rats. We identified 965 proteins across groups and significant directional changes in 67 proteins of aged and/or aged OVX; 32 proteins were unique to aged OVX. Notably, only six proteins were similarly altered in adult OVX (voltage-dependent ion channel 1, adenine nucleotide translocator 1, cytochrome c oxidase subunits VIIc and VIc, catalase, and myosin binding protein C). Proteins affected by aging were primarily related to cellular metabolism, oxidative stress, and cell death. The largest change occurred in monoamine oxidase-A (MAO-A), a source of oxidative stress. While acute MAO-A inhibition induced mild uncoupling in aged mitochondria, reductions in infarct size were not observed. Age-dependent alterations in mitochondrial signaling indicate a highly selective myocardial response to E(2) deficiency. The combined proteomic and functional approaches described here offer possibility of new protein targets for experimentation and therapeutic intervention in the aged female population.
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Registered trials
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