SynthesisAmerican journal of Alzheimer's disease and other dementias2012
Contribution of brain imaging to the understanding of gait disorders in Alzheimer's disease: a systematic review.
Synthesis in American journal of Alzheimer's disease and other dementias, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Gait and falls in cerebral small vessel disease: a systematic review and meta-analysis.Age and ageing · 2023Pooled it
- White matter integrity is associated with gait impairment and falls in mild cognitive impairment. Results from the gait and brain study.NeuroImage. Clinical · 2019Trial
- Gait Analysis Using Wearable Sensors in Patients With Alzheimer's Dementia: A Preliminary Report.Dementia and neurocognitive disorders · 2026Article
- Association of kyphosis index with decreased physical function and cognitive domain in community-dwelling older adults: a cross-sectional study.BMC geriatrics · 2025Article
- Longitudinal investigation of gait and Alzheimer's disease in adults with Down syndrome.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Development and validation of a risk prediction model for motoric cognitive risk syndrome in older adults.Aging clinical and experimental research · 2024Article
- Machine learning approach to classifying declines of physical function and muscle strength associated with cognitive function in older women: gait characteristics based on three speeds.Frontiers in public health · 2024Article
- Association of Motor Function With Cognitive Trajectories and Structural Brain Differences: A Community-Based Cohort Study.Neurology · 2023Article
- Are falls a manifestation of brain failure? Revisited 40 years later.Age and ageing · 2023Article
- Effects of motor-cognitive interaction based on dual-task gait analysis recognition in middle age to aging people with normal cognition and mild cognitive impairment.Frontiers in aging neuroscience · 2022Article
- Single-Task or Dual-Task? Gait Assessment as a Potential Diagnostic Tool for Alzheimer's Dementia.Journal of Alzheimer's disease : JAD · 2021Article
- Article
- Weaker Braking Force, A New Marker of Worse Gait Stability in Alzheimer Disease.Frontiers in aging neuroscience · 2020Article
- Guidelines for Gait Assessments in the Canadian Consortium on Neurodegeneration in Aging (CCNA).Canadian geriatrics journal : CGJ · 2018Article
- Association of Dual-Task Gait With Incident Dementia in Mild Cognitive Impairment: Results From the Gait and Brain Study.JAMA neurology · 2017Article
- β-Amyloid Burden Predicts Lower Extremity Performance Decline in Cognitively Unimpaired Older Adults.The journals of gerontology. Series A, Biological sciences and medical sciences · 2017Article
- Apolipoprotein E Genotype Linked to Spatial Gait Characteristics: Predictors of Cognitive Dual Task Gait Change.PloS one · 2016Article
- Slow gait in MCI is associated with ventricular enlargement: results from the Gait and Brain Study.Journal of neural transmission (Vienna, Austria : 1996) · 2013Article
- The Value of Handgrip Strength and Self-Rated Squat Ability in Predicting Mild Cognitive Impairment: Development and Validation of a Prediction Model.Inquiry : a journal of medical care organization, provision and financingArticle
Corrections and comments
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Authors and funding
9 authors at 4 institutions in 3 countries.
Funding
Abstract
Although gait disorders are common in Alzheimer's disease (AD), determining which brain structures and related lesions are specifically involved is a goal yet to be reached. Our objective was to systematically review all published data that examined associations between gait disorders and brain imaging in AD. Of 486 selected studies, 4 observational studies met the selection criteria. The number of participants ranged from 2 to 61 community dwellers (29%-100% female) with prodromal or dementia-stage AD. Quantitative gait disorders (ie, slower gait velocity explained by shorter stride length) were associated with white matter lesions, mainly in the medial frontal lobes and basal ganglia. The nigrostriatal dopamine system was unaffected. Qualitative gait disorders (ie, higher stride length variability) correlated with lower hippocampal volume and function. Gait disorders in AD could be explained by a high burden of age-related subcortical hyperintensities on the frontal-subcortical circuits (nonspecific) together with hippocampal atrophy and hypometabolism (specific).
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.