ArticleJournal of mathematical biology2013
Viral dynamics model with CTL immune response incorporating antiretroviral therapy.
Article in Journal of mathematical biology, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed.
- A fractional-order vaccination model to analyze the dynamics of Mpox Clade I and II with real data.Scientific reports · 2026Article
- Numerical modeling and simulation of stochastic fractional order model for COVID-19 infection in Mittag-Leffler kernel.Scientific reports · 2025Article
- Anti-CTLA-4 nanobody as a promising approach in cancer immunotherapy.Cell death & disease · 2024Review
- Impact of public sentiments on the transmission of COVID-19 across a geographical gradient.PeerJ · 2023Article
- Dynamics of a new HIV model with the activation status of infected cells.Journal of mathematical biology · 2021Article
- Fuzzy logic and Lyapunov-based non-linear controllers for HCV infection.IET systems biology · 2021Article
- A Nanobody Against Cytotoxic T-Lymphocyte Associated Antigen-4 Increases the Anti-Tumor Effects of Specific CD8Journal of biomedical nanotechnology · 2019Article
- A discrete-time analog for coupled within-host and between-host dynamics in environmentally driven infectious disease.Advances in difference equations · 2018Article
- Global Stability of Delayed Viral Infection Models with Nonlinear Antibody and CTL Immune Responses and General Incidence Rate.Computational and mathematical methods in medicine · 2016Article
- Global dynamics for discrete-time analog of viral infection model with nonlinear incidence and CTL immune response.Advances in difference equations · 2016Article
Corrections and comments
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We present two HIV models that include the CTL immune response, antiretroviral therapy and a full logistic growth term for uninfected CD4+ T-cells. The difference between the two models lies in the inclusion or omission of a loss term in the free virus equation. We obtain critical conditions for the existence of one, two or three steady states, and analyze the stability of these steady states. Through numerical simulation we find substantial differences in the reproduction numbers and the behaviour at the infected steady state between the two models, for certain parameter sets. We explore the effect of varying the combination drug efficacy on model behaviour, and the possibility of reconstituting the CTL immune response through antiretroviral therapy. Furthermore, we employ Latin hypercube sampling to investigate the existence of multiple infected equilibria.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.