ArticleBritish journal of cancer2012
Quantitative relationship between silica exposure and lung cancer mortality in German uranium miners, 1946-2003.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 1 of them a synthesis that pooled it.
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Who cites it
25 citing papers in PubMed, 1 synthesis or guideline pooled it, 49 citations in OpenAlex.
- Occupational exposure to respirable crystalline silica and lung cancer: a systematic review of cut-off points.Environmental health : a global access science source · 2023Pooled it
- Occupational disease risks in natural resource-based industries among a large cohort of workers in Ontario, Canada.Work (Reading, Mass.) · 2026Article
- Global Burden, Projection, and Inequalities Analysis of Cancer Attributable to Occupational Carcinogen Exposure in Individuals Aged Over 40 Years.Cancer medicine · 2025Article
- Article
- Risk characterization for silica-related silicosis and lung cancer in communities adjacent to sand and gravel extraction facilities: examining limitations in our current risk methods.Frontiers in public health · 2025Article
- Shared Genetic Links Between Sleep, Neurodevelopmental and Neuropsychiatric Conditions: A Genome-Wide and Pathway-Based Polygenic Score Analysis.Genes, brain, and behavior · 2024Article
- Updated risk models for lung cancer due to radon exposure in the German Wismut cohort of uranium miners, 1946-2018.Radiation and environmental biophysics · 2023Article
- Effects of spatial variation in dose delivery: what can we learn from radon-related lung cancer studies?Radiation and environmental biophysics · 2022Review
- Lung Cancer and Radon: Pooled Analysis of Uranium Miners Hired in 1960 or Later.Environmental health perspectives · 2022Article
- Modulation of Cardiopulmonary Toxicity and Oxidative Stress by Phenolic-Rich Fraction of Croton zambiscus Leaves in Rat Exposed to Chronic Mixture of Environmental Toxicants.Cardiovascular toxicology · 2021Article
- Association of 13 Occupational Carcinogens in Patients With Cancer, Individually and Collectively, 1990-2017.JAMA network open · 2021Article
- Mortality in Underground Miners in a Former Uranium Ore Mine–Results of a Cohort Study Among Former Employees of Wismut AG in Saxony and Thuringia.Deutsches Arzteblatt international · 2021Article
- Radiation-related health hazards to uranium miners.Environmental science and pollution research international · 2020Review
- Respirable Crystalline Silica Exposure, Smoking, and Lung Cancer Subtype Risks. A Pooled Analysis of Case-Control Studies.American journal of respiratory and critical care medicine · 2020Article
- PUMA - pooled uranium miners analysis: cohort profile.Occupational and environmental medicine · 2020Article
- Silica, silicosis and lung cancer: what level of exposure is acceptable?La Medicina del lavoro · 2018Article
- Exposure-Lag-Response in Longitudinal Studies: Application of Distributed-Lag Nonlinear Models in an Occupational Cohort.American journal of epidemiology · 2018Article
- Silicosis and lung cancer: current perspectives.Lung Cancer (Auckland, N.Z.) · 2018Review
- Mechanistic study on lung cancer mortality after radon exposure in the Wismut cohort supports important role of clonal expansion in lung carcinogenesis.Radiation and environmental biophysics · 2016Article
- Occupational exposures and lung cancer risk among Minnesota taconite mining workers.Occupational and environmental medicine · 2015Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn 1996 and 2009, the International Agency for Research on Cancer classified silica as carcinogenic to humans. The exposure-response relationship between silica and lung cancer risk, however, is still debated. Data from the German uranium miner cohort study were used to further investigate this relationship.
methodsThe cohort includes 58677 workers with individual information on occupational exposure to crystalline silica in mg m(-3)-years and the potential confounders radon and arsenic based on a detailed job-exposure matrix. In the follow-up period 1946-2003, 2995 miners died from lung cancer. Internal Poisson regression with stratification by age and calendar year was used to estimate the excess relative risk (ERR) per dust-year. Several models including linear, linear quadratic and spline functions were applied. Detailed adjustment for cumulative radon and arsenic exposure was performed.
resultsA piecewise linear spline function with a knot at 10 mg m(-3)-years provided the best model fit. After full adjustment for radon and arsenic no increase in risk <10 mg m(-3)-years was observed. Fixing the parameter estimate of the ERR in this range at 0 provided the best model fit with an ERR of 0.061 (95% confidence interval: 0.039, 0.083) >10 mg m(-3)-years.
conclusionThe study confirms a positive exposure-response relationship between silica and lung cancer, particularly for high exposures.
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