ArticleBritish journal of cancer2012
WNT/β-catenin pathway activation in Myc immortalised cerebellar progenitor cells inhibits neuronal differentiation and generates tumours resembling medulloblastoma.
Article in British journal of cancer, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 19 citations in OpenAlex.
- Synergistic Effects of the RARCancers · 2024Article
- SMARCC2 combined with c‑Myc inhibits the migration and invasion of glioma cells via modulation of the Wnt/β‑catenin signaling pathway.Molecular medicine reports · 2021Article
- Article
- Targeting DDX3 in Medulloblastoma Using the Small Molecule Inhibitor RK-33.Translational oncology · 2019Article
- Author Correction: Genetically engineered cerebral organoids model brain tumor formation.Nature methods · 2018Article
- Genetically engineered cerebral organoids model brain tumor formation.Nature methods · 2018Article
- CCR9-mediated signaling through β-catenin and identification of a novel CCR9 antagonist.Molecular oncology · 2015Article
- Brain tumor stem cells: Molecular characteristics and their impact on therapy.Molecular aspects of medicine · 2014Review
- Oncolytic effects of parvovirus H-1 in medulloblastoma are associated with repression of master regulators of early neurogenesis.International journal of cancer · 2014Article
- Pediatric medulloblastoma - update on molecular classification driving targeted therapies.Frontiers in oncology · 2014Review
- The histone deacetylase inhibitor sodium butyrate promotes cell death and differentiation and reduces neurosphere formation in human medulloblastoma cells.Molecular neurobiology · 2013Article
- The role of the WNT/β-catenin pathway in central nervous system primitive neuroectodermal tumours (CNS PNETs).British journal of cancer · 2013Article
- Pharmacological modulation of beta-catenin and its applications in cancer therapy.Journal of cellular and molecular medicine · 2013Review
- Signaling pathway and molecular subgroups of medulloblastoma.International journal of clinical and experimental pathology · 2013Review
- Article
- ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.Neuro-oncology advancesArticle
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundMedulloblastoma is the most common malignant childhood brain tumour. Aberrant activation of the WNT/β-catenin pathway occurs in approximately 25% of medulloblastomas. However, its role in medulloblastoma pathogenesis is not understood.
methodsWe have developed a model of WNT/β-catenin pathway-activated medulloblastoma. Pathway activation was induced in a Myc immortalised cerebellar progenitor cell line through stable expression of Wnt1. In vitro and in vivo analysis was undertaken to understand the effect of pathway activation and identify the potential cell of origin.
resultsTumours that histologically resembled classical medulloblastoma formed in vivo using cells overexpressing Wnt1, but not with the control cell line. Wnt1 overexpression inhibited neuronal differentiation in vitro, suggesting WNT/β-catenin pathway activation prevents cells terminally differentiating, maintaining them in a more 'stem-like' state. Analysis of cerebellar progenitor cell markers demonstrated the cell line resembled cells from the cerebellar ventricular zone.
conclusionWe have developed a cell line with the means of orthotopically modelling WNT/β-catenin pathway-activated medulloblastoma. We provide evidence of the role pathway activation is playing in tumour pathogenesis and suggest medulloblastomas can arise from cells other than granule cell progenitors. This cell line is a valuable resource to further understand the role of pathway activation in tumorigenesis and for investigation of targeted therapies.
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