Evidence map›Paper›PMID 22929869›Full record

ReviewThe Psychiatric clinics of North America2012

Is early intervention for psychosis feasible and effective?

Vinod H Srihari, Jai Shah, Matcheri S Keshavan

Registry-linked trialAbstract readReview
In one paragraph

Review in The Psychiatric clinics of North America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00309452 (Randomized Trial of Usual Care Versus Specialized, Phase-specific Care in the Public Sector for First Episode Psychosis.), which is not on this map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00309452 nacompletednot on this map

Randomized Trial of Usual Care Versus Specialized, Phase-specific Care in the Public Sector for First Episode Psychosis.

TypeinterventionalSponsorYale UniversityRan2006 to 2013Enrolled120ConditionsSchizophrenia and Disorders With Psychotic FeaturesArmsCognitive Behavioral Group Therapy, Cognitive remediation, Medications, MFG, Assertive case management
3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Implementation of an Adapted Fidelity Scale for Pennsylvania Coordinated Specialty Care Programs for First Episode Psychosis.Prevention science : the official journal of the Society for Prevention Research · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vinod H SrihariDepartment of Psychiatry, Yale University,and Clinic for Specialized Treatment Early in Psychosis (STEP), 34 Park Street, Connecticut Mental Health Center, Room 273A, New Haven, CT 06519, USA. vinod.srihari@yale.edu
Jai Shah
Matcheri S Keshavan

Funding

Stability of Biotypes: a Longitudinal EvaluationR01MH078113 · NIMH · WAYNE STATE UNIVERSITY · PI KESHAVAN, MATCHERI S. · 2007 to 2019
$6.2M
Brain Maturation and Vulnerability to SchizophreniaR01MH064023 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KESHAVAN, MATCHERI S. · 2003 to 2008
$3.0M
Specialized Treatment Early in Psychosis (STEP): A community health center basedRC1MH088971 · NIMH · YALE UNIVERSITY · PI SRIHARI, VINOD H. · 2009 to 2010
$750k
NIMH NIH HHS MH088971NIMH NIH HHS MH 64023NIMH NIH HHS MH 78113NIMH NIH HHS R01 MH064023NIMH NIH HHS R01 MH078113NIMH NIH HHS RC1 MH088971
6 · The paper itself

Abstract

Services that provide comprehensive, early intervention (EI) have shown promise in improving long-term outcomes in schizophrenia. This article reviews the rationale and salient concepts relevant to understanding the growing EI literature. A selective review of studies evaluating the effectiveness of integrated EI is followed by a discussion of feasibility, especially in the US context. Finally, the authors present a framework that seeks to integrate activities traditionally categorized and separated as discovery and implementation. This framework is offered as a way to advance both goals.

Indexed as

Disease ProgressionHumansPrognosisPsychotic DisordersSchizophreniaSeverity of Illness IndexTime FactorsTreatment Outcome

Identifiers

PMID22929869
PMCPMC3431510

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.