Evidence map›Paper›PMID 22929776›Full record

ArticleMethods in enzymology2012

A chemical approach to mapping nucleosomes at base pair resolution in yeast.

Kristin R Brogaard, Liqun Xi, Ji-Ping Wang, Jonathan Widom

Open access · greenAbstract read
In one paragraph

Article in Methods in enzymology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
5.4field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 30 citations in OpenAlex.

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  15. Review
  16. Article
  17. Functional roles of nucleosome stability and dynamics.Briefings in functional genomics · 2015
    Review
  18. Article
  19. Ubiquitous nucleosome crowding in the yeast genome.Proceedings of the National Academy of Sciences of the United States of America · 2014
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Kristin R BrogaardDepartment of Molecular Biosciences, Northwestern University, Evanston, Illinois, USA. Kristin.Brogaard@systemsbiology.org
Liqun Xi
Ji-Ping Wang
Jonathan Widom
Northwestern University · US

Funding

TRANS-NETWORK PROJECTSU54CA143869 · NCI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI WIDOM, JONATHAN · 2009 to 2013
$12.8M
NUCLEOSOME POSITIONINGR01GM058617 · NIGMS · NORTHWESTERN UNIVERSITY · PI UHLENBECK, OLKE C · 1999 to 2012
$4.4M
Novel Epigenetic Test for the Treatment and Improvement of Longitudinal Health-Outcomes for Men with Severe InfertilityR44HD112264 · NICHD · INHERENT BIOSCIENCES, INC. · PI BROGAARD, KRISTIN R · 2023 to 2025
$1.9M
Mathematical and Statistical Models for Nucleosome...R01GM075313 · NIGMS · NORTHWESTERN UNIVERSITY · PI WANG, JI-PING · 2005 to 2010
$1.2M
Clinical epigenetic diagnostic for spermatogenic failure and future health risksR43HD108826 · NICHD · INHERENT BIOSCIENCES, INC. · PI BROGAARD, KRISTIN R · 2022 to 2022
$255k
NCI NIH HHS U54 CA143869NICHD NIH HHS R43 HD108826NICHD NIH HHS R44 HD112264NIGMS NIH HHS R01 GM058617NIGMS NIH HHS R01GM058617NIGMS NIH HHS R01 GM075313NIGMS NIH HHS R01GM075313NIGMS NIH HHS T32GM00806
6 · The paper itself

Abstract

Most eukaryotic DNA exists in DNA-protein complexes known as nucleosomes. The exact locations of nucleosomes along the genome play a critical role in chromosome functions and gene regulation. However, the current methods for nucleosome mapping do not provide the necessary accuracy to identify the precise nucleosome locations. Here we describe a new experimental approach that directly maps nucleosome center locations in vivo genome-wide at single base pair resolution.

Indexed as

Base PairingGenome, FungalBase CompositionChromosome MappingChromosomes, FungalComputational BiologyCysteineDNA, FungalHistonesMutagenesisNucleosomesPhenotypeSaccharomyces cerevisiaeSerineTranscription FactorsCysteineDNA, FungalHistonesNucleosomesSerineTranscription Factors

Identifiers

PMID22929776
PMCPMC5101424
OpenAlexW1851625

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.