ArticleUltrasound in medicine & biology2012
Stability of echogenic liposomes as a blood pool ultrasound contrast agent in a physiologic flow phantom.
Article in Ultrasound in medicine & biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed.
- Investigation of the synergistic effect of enzymatic and Ultrasound-Induced amyloid microclot degradation.Journal of thrombosis and thrombolysis · 2026Article
- Assessment of bubble activity generated by histotripsy combined with echogenic liposomes.Physics in medicine and biology · 2022Article
- Cavitation Emissions Nucleated by Definity Infused through an EkoSonic Catheter in a Flow Phantom.Ultrasound in medicine & biology · 2021Article
- Concurrent visual and acoustic tracking of passive and active delivery of nanobubbles to tumors.Theranostics · 2020Article
- Assessment of histotripsy-induced liquefaction with diagnostic ultrasound and magnetic resonance imaging in vitro and ex vivo.Physics in medicine and biology · 2019Article
- Bactericidal Activity of Lipid-Shelled Nitric Oxide-Loaded Microbubbles.Frontiers in pharmacology · 2019Article
- Effect of Temperature on the Size Distribution, Shell Properties, and Stability of DefinityUltrasound in medicine & biology · 2018Article
- Sequential HIFU heating and nanobubble encapsulation provide efficient drug penetration from stealth and temperature sensitive liposomes in colon cancer.Journal of controlled release : official journal of the Controlled Release Society · 2017Article
- Loss of gas from echogenic liposomes exposed to pulsed ultrasound.Physics in medicine and biology · 2016Article
- Therapeutic potential of ultrasound microbubbles in gastrointestinal oncology: recent advances and future prospects.Therapeutic advances in gastroenterology · 2015Review
- Plasmin-loaded echogenic liposomes for ultrasound-mediated thrombolysis.Translational stroke research · 2015Article
- Loss of echogenicity and onset of cavitation from echogenic liposomes: pulse repetition frequency independence.Ultrasound in medicine & biology · 2015Article
- pH-triggered echogenicity and contents release from liposomes.Molecular pharmaceutics · 2014Article
- Nitric oxide pretreatment enhances atheroma component highlighting in vivo with intercellular adhesion molecule-1-targeted echogenic liposomes.Ultrasound in medicine & biology · 2014Article
- Encapsulated microbubbles and echogenic liposomes for contrast ultrasound imaging and targeted drug delivery.Computational mechanics · 2014Article
- Cavitation thresholds of contrast agents in an in vitro human clot model exposed to 120-kHz ultrasound.The Journal of the Acoustical Society of America · 2014Article
- Broadband attenuation measurements of phospholipid-shelled ultrasound contrast agents.Ultrasound in medicine & biology · 2014Article
- Relationship between cavitation and loss of echogenicity from ultrasound contrast agents.Physics in medicine and biology · 2013Article
- Clot retraction affects the extent of ultrasound-enhanced thrombolysis in an ex vivo porcine thrombosis model.Ultrasound in medicine & biology · 2013Article
- Current status and prospects for microbubbles in ultrasound theranostics.Wiley interdisciplinary reviews. Nanomedicine and nanobiotechnologyReview
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Authors and funding
6 authors.
Funding
Abstract
Echogenic liposomes (ELIP) are multifunctional ultrasound contrast agents (UCAs) with a lipid shell encapsulating both air and an aqueous core. ELIP are being developed for molecular imaging and image-guided therapeutic delivery. Stability of the echogenicity of ELIP in physiologic conditions is crucial to their successful translation to clinical use. In this study, we determined the effects of the surrounding media's dissolved air concentration, temperature transition and hydrodynamic pressure on the echogenicity of a chemically modified formulation of ELIP to promote stability and echogenicity. ELIP samples were diluted in porcine plasma or whole blood and pumped through a pulsatile flow system with adjustable hydrodynamic pressures and temperature. B-mode images were acquired using a clinical diagnostic scanner every 5 s for a total duration of 75 s. Echogenicity in porcine plasma was assessed as a function of total dissolved gas saturation. ELIP were added to plasma at room temperature (22 °C) or body temperature (37 °C) and pumped through a system maintained at 22 °C or 37 °C to study the effect of temperature transitions on ELIP echogenicity. Echogenicity at normotensive (120/80 mmHg) and hypertensive pressures (145/90 mmHg) was measured. ELIP were echogenic in plasma and whole blood at body temperature under normotensive to hypertensive pressures. Warming of samples from room temperature to body temperature did not alter echogenicity. However, in plasma cooled rapidly from body temperature to room temperature or in degassed plasma, ELIP lost echogenicity within 20 s at 120/80 mmHg. The stability of echogenicity of a modified ELIP formulation was determined in vitro at body temperature, physiologic gas concentration and throughout the physiologic pressure range. However, proper care should be taken to ensure that ELIP are not cooled rapidly from body temperature to room temperature as they will lose their echogenic properties. Further in vivo investigations will be needed to evaluate the optimal usage of ELIP as blood pool contrast agents.
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