ArticleJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism2012
Anomalous diffusion of brain metabolites evidenced by diffusion-weighted magnetic resonance spectroscopy in vivo.
Article in Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
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Who cites it
25 citing papers in PubMed, 57 citations in OpenAlex.
- Scattering approach to diffusion quantifies axonal damage in brain injury.Nature communications · 2025Article
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- Single-shot diffusion trace spectroscopic imaging using radial echo planar trajectories.Magnetic resonance in medicine · 2024Article
- Single-shot diffusion trace-weighted MR spectroscopy: Comparison with unipolar and bipolar diffusion-weighted point-resolved spectroscopy.NMR in biomedicine · 2024Article
- Macromolecular background signal and non-Gaussian metabolite diffusion determined in human brain using ultra-high diffusion weighting.Magnetic resonance in medicine · 2022Article
- Mapping complex cell morphology in the grey matter with double diffusion encoding MR: A simulation study.NeuroImage · 2021Article
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- Cytosolic diffusivity and microscopic anisotropy of N-acetyl aspartate in human white matter with diffusion-weighted MRS at 7 T.NMR in biomedicine · 2021Article
- Modeling NO Biotransport in Brain Using a Space-Fractional Reaction-Diffusion Equation.Frontiers in physiology · 2021Article
- Current and Emerging MR Methods and Outcome in Rodent Models of Parkinson's Disease: A Review.Frontiers in neuroscience · 2021Review
- Challenges for biophysical modeling of microstructure.Journal of neuroscience methods · 2020Review
- Revisiting double diffusion encoding MRS in the mouse brain at 11.7T: Which microstructural features are we sensitive to?NeuroImage · 2020Article
- Glutamate diffusion in the rat brain in vivo under light and deep anesthesia conditions.Magnetic resonance in medicine · 2019Article
- Apparent diffusion coefficients of the five major metabolites measured in the human brain in vivo at 3T.Magnetic resonance in medicine · 2018Article
- Brain Metabolite Diffusion from Ultra-Short to Ultra-Long Time Scales: What Do We Learn, Where Should We Go?Frontiers in neuroscience · 2018Article
- Metabolite diffusion up to very high b in the mouse brain in vivo: Revisiting the potential correlation between relaxation and diffusion properties.Magnetic resonance in medicine · 2017Article
- Longitudinal MR spectroscopy of neurodegeneration in multiple sclerosis with diffusion of the intra-axonal constituentNeuroImage. Clinical · 2017Article
- Probing metabolite diffusion at ultra-short time scales in the mouse brain using optimized oscillating gradients and "short"-echo-time diffusion-weighted MRS.NMR in biomedicine · 2017Article
- Distinguishing neuronal from astrocytic subcellular microstructures using in vivo Double Diffusion Encoded 1H MRS at 21.1 T.PloS one · 2017Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Translational displacement of molecules within cells is a key process in cellular biology. Molecular motion potentially depends on many factors, including active transport, cytosol viscosity and molecular crowding, tortuosity resulting from cytoskeleton and organelles, and restriction barriers. However, the relative contribution of these factors to molecular motion in the cytoplasm remains poorly understood. In this work, we designed an original diffusion-weighted magnetic resonance spectroscopy strategy to probe molecular motion at subcellular scales in vivo. This led to the first observation of anomalous diffusion, that is, dependence of the apparent diffusion coefficient (ADC) on the diffusion time, for endogenous intracellular metabolites in the brain. The observed increase of the ADC at short diffusion time yields evidence that metabolite motion is characteristic of hindered random diffusion rather than active transport, for time scales up to the dozen milliseconds. Armed with this knowledge, data modeling based on geometrically constrained diffusion was performed. Results suggest that metabolite diffusion occurs in a low-viscosity cytosol hindered by ∼2-μm structures, which is consistent with known intracellular organization.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.