ArticleBreast cancer research : BCR2012
Tumour morphology of early-onset breast cancers predicts breast cancer risk for first-degree relatives: the Australian Breast Cancer Family Registry.
Article in Breast cancer research : BCR, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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7 citing papers in PubMed, 10 citations in OpenAlex.
- Review
- Recurrent Germline BRCA2 Gene Mutation in Lithuanian Family.Medicina (Kaunas, Lithuania) · 2020Article
- Mortality after breast cancer as a function of time since diagnosis by estrogen receptor status and age at diagnosis.International journal of cancer · 2019Article
- DNA Methylation in Breast Tumor from High-risk Women in the Breast Cancer Family Registry.Anticancer research · 2017Article
- Article
- Tumour morphology predicts PALB2 germline mutation status.British journal of cancer · 2013Article
- PALB2 and breast cancer: ready for clinical translation!The application of clinical genetics · 2013Article
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6 authors at 1 institution in 1 country.
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Abstract
introductionWe hypothesised that breast cancer risk for relatives of women with early-onset breast cancer could be predicted by tumour morphological features.
methodsWe studied female first-degree relatives of a population-based sample of 452 index cases with a first primary invasive breast cancer diagnosed before the age of 40 years. For the index cases, a standardised tumour morphology review had been conducted for all; estrogen (ER) and progesterone receptor (PR) status was available for 401 (89%), and 77 (17%) had a high-risk mutation in a breast cancer susceptibility gene or methylation of the BRCA1 promoter region in peripheral blood DNA. We calculated standardised incidence ratios (SIR) by comparing the number of mothers and sisters with breast cancer with the number expected based on Australian incidence rates specific for age and year of birth.
resultsUsing Cox proportional hazards modelling, absence of extensive sclerosis, extensive intraductal carcinoma, absence of acinar and glandular growth patterns, and the presence of trabecular and lobular growth patterns were independent predictors with between a 1.8- and 3.1-fold increased risk for relatives (all P <0.02). Excluding index cases with known genetic predisposition or BRCA1 promoter methylation, absence of extensive sclerosis, circumscribed growth, extensive intraductal carcinoma and lobular growth pattern were independent predictors with between a 2.0- and 3.3-fold increased risk for relatives (all P <0.02). Relatives of the 128 (34%) index cases with none of these four features were at population risk (SIR = 1.03, 95% CI = 0.57 to 1.85) while relatives of the 37 (10%) index cases with two or more features were at high risk (SIR = 5.18, 95% CI = 3.22 to 8.33).
conclusionsThis wide variation in risks for relatives based on tumour characteristics could be of clinical value, help discover new breast cancer susceptibility genes and be an advance on the current clinical practice of using ER and PR as pathology-based predictors of familial and possibly genetic risks.
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