ArticleEpigenetics & chromatin2012
Selected imprinting of INS in the marsupial.
Article in Epigenetics & chromatin, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed, 34 citations in OpenAlex.
- The marsupial imprinted gene MLH1 has retrocopies in three marsupial families.Epigenetics & chromatin · 2026Article
- ZFP57 is a regulator of postnatal growth and life-long health.Nature communications · 2026Article
- Review
- Marsupials have monoallelic MEST expression with a conserved antisense lncRNA but MEST is not imprinted.Heredity · 2024Article
- Placental imprinting of SLC22A3 in the IGF2R imprinted domain is conserved in therian mammals.Epigenetics & chromatin · 2022Article
- Molecular Signatures of Placentation and Secretion Uncovered in Poeciliopsis Maternal Follicles.Molecular biology and evolution · 2020Article
- Landscape of genomic imprinting and its functions in the mouse mammary gland.Journal of molecular cell biology · 2020Article
- Identification of a novel antisense noncoding RNA, ALID, transcribed from the putative imprinting control region of marsupial IGF2R.Epigenetics & chromatin · 2018Article
- Article
- The coadaptation theory for genomic imprinting.Evolution letters · 2017Article
- Post-natal imprinting: evidence from marsupials.Heredity · 2014Review
- Review
- Maternal regulation of offspring development in mammals is an ancient adaptation tied to lactation.Applied & translational genomics · 2013Review
- Postnatal epigenetic reprogramming in the germline of a marsupial, the tammar wallaby.Epigenetics & chromatin · 2013Article
- The origin and evolution of genomic imprinting and viviparity in mammals.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2013Review
- Review
- Article
- Placentation in Marsupials.Advances in anatomy, embryology, and cell biologyArticle
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
unlabelled
backgroundIn marsupials, growth and development of the young occur postnatally, regulated by milk that changes in composition throughout the long lactation. To initiate lactation in mammals, there is an absolute requirement for insulin (INS), a gene known to be imprinted in the placenta. We therefore examined whether INS is imprinted in the mammary gland of the marsupial tammar wallaby (Macropus eugenii) and compared its expression with that of insulin-like growth factor 2 (IGF2).
resultsINS was expressed in the mammary gland and significantly increased, while IGF2 decreased, during established milk production. Insulin and IGF2 were both detected in the mammary gland macrophage cells during early lactation and in the alveolar cells later in lactation. Surprisingly, INS, which was thought only to be imprinted in the therian yolk sac, was imprinted and paternally expressed in the liver of the developing young, monoallelically expressed in the tammar mammary gland and biallelic in the stomach and intestine. The INS transcription start site used in the liver and mammary gland was differentially methylated.
conclusionsThis is the first study to identify tissue-specific INS imprinting outside the yolk sac. These data suggest that there may be an advantage of selective monoallelic expression in the mammary gland and that this may influence the growth of the postnatal young. These results are not consistent with the parental conflict hypothesis, but instead provide support for the maternal-infant co-adaptation hypothesis. Thus, imprinting in the mammary gland maybe as critical for postnatal growth and development in mammals as genomic imprinting in the placenta is prenatally.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.