Evidence map›Paper›PMID 22929095›Full record

ReviewClinics in chest medicine2012

Biomarkers in asthma: a real hope to better manage asthma.

Serpil C Erzurum, Benjamin M Gaston

Abstract readReview
In one paragraph

Review in Clinics in chest medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed.

  1. Effects of Family-Supported Healthcare on Children with Asthma.Therapeutics and clinical risk management · 2024
    Article
  2. Diagnostic value of IL-6 for patients with asthma: a meta-analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023
    Review
  3. Review
  4. Article
  5. Metabolomic Endotype of Asthma.Journal of immunology (Baltimore, Md. : 1950) · 2015
    Article
  6. Article
  7. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Serpil C ErzurumDepartment of Pathobiology, Lerner Research Institute, Cleveland Clinic Lerner College of Medicine-CWRU, 9500 Euclid Avenue, NC22, Cleveland, OH 44195-0001, USA. erzurus@ccf.org
Benjamin M Gaston

Funding

Clinical and Translational Science Collaborative of ClevelandUL1TR000439 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI KONSTAN, MICHAEL W. · 2012 to 2016
$50.0M
Targeting pathological hyaluronan matricesP01HL103453 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI ERZURUM, SERPIL C. · 2011 to 2020
$26.8M
S-nitrosothiol signaling in pulmonary epithelial cellsP01HL101871 · NHLBI · UNIVERSITY OF VIRGINIA · PI GASTON, BENJAMIN, LEWIS, STEPHEN JOHN · 2011 to 2015
$8.7M
Airway redox biochemistry as a deteriminant of asthma phenotype during adolescen*U10HL109250 · NHLBI · UNIVERSITY OF VIRGINIA · PI ERZURUM, SERPIL C., GASTON, BENJAMIN · 2011 to 2016
$4.2M
S-NITROSOTHIOL BREAKDOWN BY AIRWAY EPITHELIAL CELLSR01HL059337 · NHLBI · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI ZAMAN, KHALEQUZ · 1999 to 2011
$3.0M
NCATS NIH HHS UL1 TR000439NHLBI NIH HHS P01 HL101871NHLBI NIH HHS P01HL101871NHLBI NIH HHS P01 HL103453NHLBI NIH HHS R01 HL059337NHLBI NIH HHS R01 HL59337NHLBI NIH HHS U10 HL109250NHLBI NIH HHS U10HL109250
6 · The paper itself

Abstract

Diagnosis and treatment of asthma are currently based on assessment of patient symptoms and physiologic tests of airway reactivity. Research over the past decade has identified an array of biochemical and cellular biomarkers, which reflect the heterogeneous and multiple mechanistic pathways that may lead to asthma. These mechanistic biomarkers offer hope for optimal design of therapies targeting the specific pathways that lead to inflammation. This article provides an overview of blood, urine, and airway biomarkers; summarizes the pathologic pathways that they signify; and begins to describe the utility of biomarkers in the future care of patients with asthma.

Indexed as

AsthmaBiomarkersHumansInflammationPhenotypeSeverity of Illness IndexBiomarkers

Identifiers

PMID22929095
PMCPMC3494969

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.