Evidence map›Paper›PMID 22929027›Full record

ArticleEuropean journal of human genetics : EJHG2013

The frequency of an IL-18-associated haplotype in Africans.

Simon R Thompson, Steve E Humphries, Mark G Thomas, Rosemary Ekong, Ayele Tarekegn, Endeshaw Bekele, Olivia Creemer, Neil Bradman, Krishna R Veeramah

Open access · bronzeAbstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in European journal of human genetics : EJHG, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 89% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 4 countries.

Simon R ThompsonUCL Centre for Cardiovascular Genetics, Rayne Institute, London, UK.
Steve E Humphries
Mark G Thomas
Rosemary Ekong
Ayele Tarekegn
Endeshaw Bekele
Olivia Creemer
Neil Bradman
Krishna R Veeramah
University College London · GBAddis Ababa University · ETUniversity of Arizona · USUppsala University · SE

Funding

British Heart Foundation FS/04/039British Heart Foundation RG/08/008/25291British Heart Foundation RG2008/08PHS HHS NHIBI 33014
6 · The paper itself

Abstract

Variation within the gene for the proinflammatory cytokine interleukin (IL)-18 has been associated with inter-individual differences in levels of free protein and disease risk. We investigated the frequency of function-associated IL18 gene haplotypes in an extensive sample (n=2357) of African populations from across the continent. A previously identified five tagging SNP (single-nucleotide polymorphism) haplotype (here designated hGTATA), known to be associated with lower levels of IL-18, was observed at a frequency of 27% in a British population of recent European ancestry, but was found at low frequency (<8%) or completely absent in African populations. Potentially protective variants may, as a consequence, be found at low frequency in African individuals and may confer a difference in disease risk.

Indexed as

Gene FrequencyHaplotypesAdultAfricaBlack PeopleHumansInterleukin-8MaleMiddle AgedPolymorphism, Single NucleotideUnited KingdomCXCL8 protein, humanInterleukin-8

Identifiers

PMID22929027
PMCPMC3598319
OpenAlexW2099447076

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.