ArticleAutism research and treatment2012
HLA Immune Function Genes in Autism.
Article in Autism research and treatment, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 54 citations in OpenAlex.
- Long-Term Risk of Rheumatoid Arthritis in Individuals With Autism Spectrum Disorder: A Population-Based Matched Cohort Study.Autism research : official journal of the International Society for Autism Research · 2026Article
- Genetic etiology of autism spectrum disorder in the African population: a scoping review.Frontiers in genetics · 2024Article
- Molecular and Cellular Insights: A Focus on Glycans and the HNK1 Epitope in Autism Spectrum Disorder.International journal of molecular sciences · 2023Article
- Exploring the molecular mechanism of comorbidity of autism spectrum disorder and inflammatory bowel disease by combining multiple data sets.Journal of translational medicine · 2023Article
- Review
- Risk of attention deficit hyperactivity and autism spectrum disorders among the children of parents with autoimmune diseases: a nationwide birth cohort study.European child & adolescent psychiatry · 2023Article
- Maternal autoimmune disease and risk of offspring autism spectrum disorder - a nationwide population-based cohort study.Frontiers in psychiatry · 2023Article
- Sex Differences in Neurodevelopmental Disorders: A Key Role for the Immune System.Current topics in behavioral neurosciences · 2023Article
- Systemic maternal inflammation promotes ASD via IL-6 and IFN-γ.Bioscience reports · 2022Review
- Maternal-fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study.Clinical epigenetics · 2022Article
- Immune Dysregulation in Autism Spectrum Disorder: What Do We Know about It?International journal of molecular sciences · 2022Review
- A Unifying Theory for Autism: The Pathogenetic Triad as a Theoretical Framework.Frontiers in psychiatry · 2021Article
- Transcriptome signatures from discordant sibling pairs reveal changes in peripheral blood immune cell composition in Autism Spectrum Disorder.Translational psychiatry · 2020Article
- Non-classical human leukocyte antigen class I in Tunisian children with autism.Central-European journal of immunology · 2020Article
- The Co-existence of ADHD With Autism in Saudi Children: An Analysis Using Next-Generation DNA Sequencing.Frontiers in genetics · 2020Article
- Comparative analysis of gene expression profiles in children with type 1 diabetes mellitus.Molecular medicine reports · 2019Article
- Covariate-dependent negative binomial factor analysis of RNA sequencing data.Bioinformatics (Oxford, England) · 2018Article
- Neuroimmunologic and Neurotrophic Interactions in Autism Spectrum Disorders: Relationship to Neuroinflammation.Neuromolecular medicine · 2018Review
- Association of HLA alleles with autism.Neuropsychiatric disease and treatment · 2018Article
- The putative role of environmental aluminium in the development of chronic neuropathology in adults and children. How strong is the evidence and what could be the mechanisms involved?Metabolic brain disease · 2017Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
The human leukocyte antigen (HLA) genes on chromosome 6 are instrumental in many innate and adaptive immune responses. The HLA genes/haplotypes can also be involved in immune dysfunction and autoimmune diseases. It is now becoming apparent that many of the non-antigen-presenting HLA genes make significant contributions to autoimmune diseases. Interestingly, it has been reported that autism subjects often have associations with HLA genes/haplotypes, suggesting an underlying dysregulation of the immune system mediated by HLA genes. Genetic studies have only succeeded in identifying autism-causing genes in a small number of subjects suggesting that the genome has not been adequately interrogated. Close examination of the HLA region in autism has been relatively ignored, largely due to extraordinary genetic complexity. It is our proposition that genetic polymorphisms in the HLA region, especially in the non-antigen-presenting regions, may be important in the etiology of autism in certain subjects.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.