ReviewOxidative medicine and cellular longevity2012
Growth culture conditions and nutrient signaling modulating yeast chronological longevity.
Review in Oxidative medicine and cellular longevity, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed.
- Exploring the anti-aging potential of natural products and plant extracts in budding yeastF1000Research · 2023Review
- An Optimized Competitive-Aging Method Reveals Gene-Drug Interactions Underlying the Chronological Lifespan ofFrontiers in genetics · 2020Article
- Article
- Nitrogen and carbon source balance determines longevity, independently of fermentative or respiratory metabolism in the yeast Saccharomyces cerevisiae.Oncotarget · 2016Article
- Dietary Restriction and Nutrient Balance in Aging.Oxidative medicine and cellular longevity · 2016Review
- Ammonium is a key determinant on the dietary restriction of yeast chronological aging in culture medium.Oncotarget · 2015Article
- The Aspergillus nidulans ATM kinase regulates mitochondrial function, glucose uptake and the carbon starvation response.G3 (Bethesda, Md.) · 2014Article
- Ammonium-dependent shortening of CLS in yeast cells starved for essential amino acids is determined by the specific amino acid deprived, through different signaling pathways.Oxidative medicine and cellular longevity · 2013Article
Corrections and comments
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The manipulation of nutrient-signaling pathways in yeast has uncovered the impact of environmental growth conditions in longevity. Studies using calorie restriction show that reducing glucose concentration of the culture media is sufficient to increase replicative and chronological lifespan (CLS). Other components of the culture media and factors such as the products of fermentation have also been implicated in the regulation of CLS. Acidification of the culture media mainly due to acetic acid and other organic acids production negatively impacts CLS. Ethanol is another fermentative metabolite capable of inducing CLS reduction in aged cells by yet unknown mechanisms. Recently, ammonium was reported to induce cell death associated with shortening of CLS. This effect is correlated to the concentration of NH(4) (+) added to the culture medium and is particularly evident in cells starved for auxotrophy-complementing amino acids. Studies on the nutrient-signaling pathways regulating yeast aging had a significant impact on aging-related research, providing key insights into mechanisms that modulate aging and establishing the yeast as a powerful system to extend knowledge on longevity regulation in multicellular organisms.
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Registered trials
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