ArticlePloS one2012
Epigenetic modification of gene expression in honey bees by heterospecific gland secretions.
Article in PloS one, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 31 citations in OpenAlex.
- A New Approach Integrating Brood-Associated Semiochemicals with Additional Feeding for Honey Bee (Insects · 2026Article
- Exploring fatty acids from royal jelly as a source of histone deacetylase inhibitors: from the hive to applications in human well-being and health.Epigenetics · 2024Article
- MicroRNA profiling of royal jelly extracellular vesicles and their potential role in cell viability and reversing cell apoptosis.Functional & integrative genomics · 2023Article
- Feeding Asian honeybee queens with European honeybee royal jelly alters body color and expression of related coding and non-coding RNAs.Frontiers in physiology · 2023Article
- Antibiotics Alter the Expression of Genes Related to Behavioral Development in Honey Bees (Hymenoptera: Apidae).Journal of insect science (Online) · 2022Article
- Investigation of the transability of dietary small non-coding RNAs to animals.Frontiers in genetics · 2022Article
- Comparative Identification of MicroRNAs inInsects · 2019Article
- Uptake and impact of natural diet-derived small RNA in invertebrates: Implications for ecology and agriculture.RNA biology · 2017Review
- MicroRNAs in Honey Bee Caste Determination.Scientific reports · 2016Article
- Negligible uptake and transfer of diet-derived pollen microRNAs in adult honey bees.RNA biology · 2016Article
- What do studies of insect polyphenisms tell us about nutritionally-triggered epigenomic changes and their consequences?Nutrients · 2015Review
- The Effects of Royal Jelly on Fitness Traits and Gene Expression in Drosophila melanogaster.PloS one · 2015Article
- Characterisation of the small RNAs in the biomedically important green-bottle blowfly Lucilia sericata.PloS one · 2015Article
- Proteomic analysis of Apis cerana and Apis mellifera larvae fed with heterospecific royal jelly and by CSBV challenge.PloS one · 2014Article
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Corrections and comments
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Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundIn the honey bee (Apis mellifera), queen and workers have different behavior and reproductive capacity despite possessing the same genome. The primary substance that leads to this differentiation is royal jelly (RJ), which contains a range of proteins, amino acids, vitamins and nucleic acids. MicroRNA (miRNA) has been found to play an important role in regulating the expression of protein-coding genes and cell biology. In this study, we characterized the miRNAs in RJ from two honey bee sister species and determined their possible effect on transcriptome in one species. METHODOLOGY/PRINCIPAL
findingsWe sequenced the miRNAs in RJ either from A. mellifera (RJM) or A. cerana (RJC). We then determined the global transcriptomes of adult A. mellifera developed from larvae fed either with RJM (mRJM) or RJC (mRJC). Finally we analyzed the target genes of those miRNA that are species specific or differentially expressed in the two honey bee species. We show that there were differences in miRNA between RJM and RJC, and that transcriptomes of adult A. mellifera were affected by the two types of RJ. A high proportion (23.3%) of the affected genes were target genes of differential miRNAs.
conclusionWe show for the first time that there are differences in miRNAs in RJ between A. mellifera and A. cerana. Further, the differences in transcriptomes of bees reared from these two RJs might be related to miRNA differences of the two species. This study provides the first evidence that heterospecific royal jelly can modify gene expression in honey bees through an epigenetic mechanism.
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