ArticlePLoS pathogens2012
The Irish potato famine pathogen Phytophthora infestans translocates the CRN8 kinase into host plant cells.
Article in PLoS pathogens, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- The role of toxin/antidote genes in the maintenance and evolution of accessory chromosomes in Fusarium.Genetics · 2025Article
- The virulence function of RXLR effectorVirulence · 2025Article
- Pathogenicity and virulence ofVirulence · 2025Review
- AScience advances · 2025Article
- Identification and Characterization of High-Molecular-Weight Proteins Secreted byJournal of fungi (Basel, Switzerland) · 2024Article
- Identification of Phytophthora cinnamomi CRN effectors and their roles in manipulating cell death during Persea americana infection.BMC genomics · 2024Article
- Deciphering the underlying immune network of the potato defense response inhibition byFrontiers in plant science · 2023Article
- Unraveling Plant Cell Death duringMicroorganisms · 2022Review
- Systematic identification and functional characterization of the CFEM proteins in poplar fungusFrontiers in cellular and infection microbiology · 2022Article
- A Phytophthora sojae CRN effector mediates phosphorylation and degradation of plant aquaporin proteins to suppress host immune signaling.PLoS pathogens · 2021Article
- Organize, Don't Agonize: Strategic Success ofMicroorganisms · 2020Review
- Effectors of Phytophthora pathogens are powerful weapons for manipulating host immunity.Planta · 2019Review
- Arms race: diverse effector proteins with conserved motifs.Plant signaling & behavior · 2019Article
- Systematic Y2H Screening Reveals Extensive Effector-Complex Formation.Frontiers in plant science · 2019Article
- The Nuclear-Localized RxLR Effector PvAvh74 FromFrontiers in microbiology · 2019Article
- Quantitative Proteomics of Potato Leaves Infected withInternational journal of molecular sciences · 2019Article
- Random mutagenesis screen shows that Phytophthora capsici CRN83_152-mediated cell death is not required for its virulence function(s).Molecular plant pathology · 2018Article
- Article
- Phytophthora cinnamomi.Molecular plant pathology · 2018Article
- RiCRN1, a Crinkler Effector From the Arbuscular Mycorrhizal FungusFrontiers in microbiology · 2018Article
Corrections and comments
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- Erratum issued
Authors and funding
7 authors.
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Abstract
Phytopathogenic oomycetes, such as Phytophthora infestans, secrete an arsenal of effector proteins that modulate plant innate immunity to enable infection. We describe CRN8, a host-translocated effector of P. infestans that has kinase activity in planta. CRN8 is a modular protein of the CRN effector family. The C-terminus of CRN8 localizes to the host nucleus and triggers cell death when the protein is expressed in planta. Cell death induction by CRN8 is dependent on its localization to the plant nucleus, which requires a functional nuclear localization signal (NLS). The C-terminal sequence of CRN8 has similarity to a serine/threonine RD kinase domain. We demonstrated that CRN8 is a functional RD kinase and that its auto-phosphorylation is dependent on an intact catalytic site. Co-immunoprecipitation experiments revealed that CRN8 forms a dimer or multimer. Heterologous expression of CRN8 in planta resulted in enhanced virulence by P. infestans. In contrast, in planta expression of the dominant-negative CRN8(R469A;D470A) resulted in reduced P. infestans infection, further implicating CRN8 in virulence. Overall, our results indicate that similar to animal parasites, plant pathogens also translocate biochemically active kinase effectors inside host cells.
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