ArticleInternational journal of nanomedicine2012
In vitro removal of toxic heavy metals by poly(γ-glutamic acid)-coated superparamagnetic nanoparticles.
Article in International journal of nanomedicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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13 citing papers in PubMed, 51 citations in OpenAlex.
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- Heavy Metal Removal from Wastewater Using Poly(Gamma-Glutamic Acid)-Based Hydrogel.Gels (Basel, Switzerland) · 2024Article
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- Nano Selenium-Enriched Probiotics as Functional Food Products against Cadmium Liver Toxicity.Materials (Basel, Switzerland) · 2021Article
- Natural bio-based monomers for biomedical applications: a review.Biomaterials research · 2021Review
- Size-dependent tissue-specific biological effects of core-shell structured FeJournal of nanobiotechnology · 2019Article
- SPIONs Prepared in Air through Improved Synthesis Methodology: The Influence of γ-FeNanomaterials (Basel, Switzerland) · 2019Article
- Convenient pH-responsive removal of Acid Black 1 by green l-histidine/iron oxide magnetic nanoadsorbent from water: performance and mechanistic studies.RSC advances · 2019Article
- Increased Production of the Value-Added Biopolymers Poly(Frontiers in bioengineering and biotechnology · 2019Article
- Poly-γ-glutamic Acid Synthesis, Gene Regulation, Phylogenetic Relationships, and Role in Fermentation.International journal of molecular sciences · 2017Review
- Microbial synthesis of poly-γ-glutamic acid: current progress, challenges, and future perspectives.Biotechnology for biofuels · 2016Review
- Content of toxic and essential metals in recrystallized and washed table salt in Shiraz, Iran.Journal of environmental health science & engineering · 2014Article
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Authors and funding
2 authors at 1 institution in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
backgroundChelation therapy involving organic chelators for treatment of heavy metal intoxication can cause cardiac arrest, kidney overload, mineral deficiency, and anemia.
methodsIn this study, superparamagnetic iron oxide nanoparticles (SPIONs) modified with an edible biopolymer poly(γ-glutamic acid) (PGA) were synthesized by coprecipitation method, characterized and evaluated for their removal efficiency of heavy metals from a metal solution, and simulated gastrointestinal fluid (SGIF).
resultsInstrumental characterization of bare- and PGA-SPIONs revealed 7% coating of PGA on SPIONs with a spherical shape and an iron oxide spinel structure belonging to magnetite. The particle sizes as determined from transmission electron microscopy images were 8.5 and 11.7 nm for bare- and PGA-SPIONs, respectively, while the magnetization values were 70.3 and 61.5 emu/g. Upon coating with PGA, the zeta potentials were shifted from positive to negative at most of the environmental pH (3-8) and biological pH (1-8), implying good dispersion in aqueous suspension and favorable conditions for heavy metal removal. Batch studies showed rapid removal of lead and cadmium with the kinetic rates estimated by pseudo-second-order model being 0.212 and 0.424 g/mg · min, respectively. A maximum removal occurred in the pH range 4-8 in deionized water and 5-8 in SGIF corresponding to most gastrointestinal pH except for the stomach. Addition of different ionic strengths (0.001-1 M sodium acetate) and essential metals (Cu, Fe, Zn, Mg, Ca, and K) did not show any marked influence on lead removal by PGA-SPIONs, but significantly reduced the binding of cadmium. Compared to deionized water, the lead removal from SGIF was high at all pH with the Langmuir monolayer removal capacity being 98.70 mg/g for the former and 147.71 mg/g for the latter. However, a lower cadmium removal capacity was shown for SGIF (23.15 mg/g) than for deionized water (31.13 mg/g).
conclusionThese results suggest that PGA-SPIONs could be used as a metal chelator for clinical treatment of metal poisoning.
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