Evidence map›Paper›PMID 22927733›Full record

ArticleClinical ophthalmology (Auckland, N.Z.)2012

Five-year visual results of intravitreal bevacizumab in refractory inflammatory ocular neovascularization.

Ahmad M Mansour, Friederike Mackensen, Padmamalini Mahendradas, Moncef Khairallah, Timothy Yy Lai, Ziad Bashshur

Open access · goldAbstract readCase Reports
In one paragraph

Article in Clinical ophthalmology (Auckland, N.Z.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.3field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 24 citations in OpenAlex.

  1. Trial
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  7. Review
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  9. Aflibercept for inflammatory choroidal neovascularization with persistent fluid on intravitreal ranibizumab therapy.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 6 institutions in 5 countries.

Ahmad M MansourDepartment of Ophthalmology, American University of Beirut, Beirut, Lebanon.
Friederike Mackensen
Padmamalini Mahendradas
Moncef Khairallah
Timothy Yy Lai
Ziad Bashshur
American University of Beirut · LBHeidelberg University · DEHong Kong Eye Hospital · CNHospital Fatuma Bourguiba Monastir · TNNarayana Nethralaya · INRafik Hariri University Hospital · LB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess the 5-year visual outcome of intravitreal bevacizumab in inflammatory ocular neovascularization.

methodsRetrospective, multicenter, consecutive case series of eight patients with inflammatory ocular neovascularization refractory to standard therapy who were treated with intravitreal bevacizumab and followed for 5 years after first injection. The outcome measures included improvement of best-corrected visual acuity expressed as logarithm of minimum angle of resolution.

resultsMean best-corrected visual acuity significantly improved from 0.58 at baseline (6/23 or 20/76; standard deviation = 0.32) to 0.20 at final assessment (6/10 or 20/32; standard deviation = 0.25) (n = 8; P = 0.02), a gain of 3.8 lines (median: three injections; eight eyes; eight patients). No ocular or systemic complications from intravitreal bevacizumab were noted.

conclusionAt 5 years, intravitreal bevacizumab sustained significant visual improvement in ocular neovascularization due to a variety of inflammatory ocular diseases without major complications after a median of three injections.

Indexed as

bevacizumabchoroidal neovascularizationpunctate inner choroidopathytoxoplasmosisuveitisVogt-Koyanagi-Harada syndrome

Identifiers

PMID22927733
PMCPMC3422149
OpenAlexW2058805950

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.