ReviewInfectious diseases in obstetrics and gynecology2012
Contraception for the HIV-positive woman: a review of interactions between hormonal contraception and antiretroviral therapy.
Review in Infectious diseases in obstetrics and gynecology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 144 citations in OpenAlex.
- Brief Report: Hormonal Contraception Use and Cabotegravir Pharmacokinetics in HIV-Uninfected Women Enrolled in HPTN 077.Journal of acquired immune deficiency syndromes (1999) · 2020Trial
- A randomized clinical trial on the effects of progestin contraception in the genital tract of HIV-infected and uninfected women in Lilongwe, Malawi: Addressing evolving research priorities.Contemporary clinical trials · 2017Trial
- The effect of protease inhibitors on the cervical mucus of HIV-positive women taking norethindrone contraception.The European journal of contraception & reproductive health care : the official journal of the European Society of Contraception · 2015Trial
- Unmet patient needs and information gaps in fertility counseling for persons living with HIV/AIDS: Evidence from Ghana.PLOS global public health · 2026Article
- Knowledge and Attitudes on Contraception and Reproductive Health in Women With HIV.Open forum infectious diseases · 2024Article
- Experiences of women on the use of Implanon NXT in Gauteng province, South Africa: A qualitative study.Health SA = SA Gesondheid · 2024Article
- Early removal of etonogestrel subcutaneous contraceptive implant at a community health centre in Pretoria.South African family practice : official journal of the South African Academy of Family Practice/Primary Care · 2022Article
- A phase 1, open-label study to evaluate the drug interaction between islatravir (MK-8591) and the oral contraceptive levonorgestrel/ethinyl estradiol in healthy adult females.Journal of the International AIDS Society · 2021Article
- In vitro assessment of the potential for dolutegravir to affect hepatic clearance of levonorgestrel.HIV medicine · 2021Article
- Cardiovascular Disease Risk Among Transgender People with HIV.Current HIV/AIDS reports · 2021Review
- Fertility desires of people living with HIV: does the implementation of a sexual and reproductive health and HIV integration model change healthcare providers' attitudes and clients' desires?BMC health services research · 2021Article
- Interactions between Hormonal Contraception and Anti-Retroviral Therapy: An Updated Review.Current obstetrics and gynecology reports · 2020Article
- Modern contraceptive use among postpartum women living with HIV attending mother baby care points in Kabarole District, Uganda.BMC women's health · 2020Article
- Immediate Postpartum Intrauterine Device in HIV-Infected Women: Experience from a Tertiary Care Center in Côte d'Ivoire.Journal of obstetrics and gynaecology of India · 2020Article
- Article
- Preferred Product Attributes of Potential Multipurpose Prevention Technologies for Unintended Pregnancy and Sexually Transmitted Infections or HIV Among U.S. Women.Journal of women's health (2002) · 2019Article
- The Evolving Role of Pharmacists in Transgender Health Care.Transgender health · 2019Review
- Pregnancy intention and contraceptive use among HIV-positive Malawian women at 4-26 weeks post-partum: A nested cross-sectional study.PloS one · 2019Article
- Physiologically based pharmacokinetic modelling prediction of the effects of dose adjustment in drug-drug interactions between levonorgestrel contraceptive implants and efavirenz-based ART.The Journal of antimicrobial chemotherapy · 2018Article
- From Pill to Condom, or Nothing at all: HIV Diagnosis and Discontinuation of Highly Effective Contraceptives Among Women in Northeast Brazil.AIDS and behavior · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPreventing unintended pregnancy in HIV-positive women can significantly reduce maternal-to-child HIV transmission as well as improve the woman's overall health. Hormonal contraceptives are safe and effective means to avoid unintended pregnancy, but there is concern that coadministration of antiretroviral drugs may alter contraceptive efficacy. MATERIALS AND
methodsWe performed a literature search of PubMed and Ovid databases of articles published between January 1980 and February 2012 to identify English-language reports of drug-drug interactions between hormonal contraceptives (HCs) and antiretroviral drugs (ARVs). We also reviewed the FDA prescribing information of contraceptive hormone preparations and antiretrovirals for additional data and recommendations.
resultsTwenty peer-reviewed publications and 42 pharmaceutical package labels were reviewed. Several studies of combined oral contraceptive pills (COCs) identified decreased serum estrogen and progestin levels when coadministered with certain ARVs. The contraceptive efficacy of injectable depot medroxyprogesterone acetate (DMPA) and the levonorgestrel intrauterine system (LNG-IUS) were largely unaffected by ARVs, while data on the contraceptive patch, ring, and implant were lacking.
conclusionsHIV-positive women should be offered a full range of hormonal contraceptive options, with conscientious counseling about possible reduced efficacy of COCs and the contraceptive implant when taken with ARVs. DMPA and the LNG-IUS maintain their contraceptive efficacy when taken with ARVs.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.