ArticleSchizophrenia bulletin2013
Diagnostic specificity of neurophysiological endophenotypes in schizophrenia and bipolar disorder.
Article in Schizophrenia bulletin, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 60 citations in OpenAlex.
- Uncovering key predictive channels and clinical variables in the gamma band auditory steady-state response in early-stage psychosis: a longitudinal study.Acta neuropsychiatrica · 2024Article
- How to Solve Clinical Challenges in Mood Disorders; Machine Learning Approaches Using Electrophysiological Markers.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2024Review
- The Use of Event-Related Potentials in the Study of Schizophrenia: An Overview.Advances in neurobiology · 2024Review
- Double dissociation between P300 components and task switch error type in healthy but not psychosis participants.Schizophrenia research · 2023Article
- Developing a clinical decision tool based on electroretinogram to monitor the risk of severe mental illness.BMC psychiatry · 2022Article
- Event-related potential correlates of affective response inhibition in bipolar I disorder: Comparison with schizophrenia.Journal of affective disorders · 2022Article
- Psychosis Biotypes: Replication and Validation from the B-SNIP Consortium.Schizophrenia bulletin · 2022Article
- Associations of the serum kynurenine pathway metabolites with P50 auditory gating in non-smoking patients with first-episode schizophrenia.Frontiers in psychiatry · 2022Article
- Auditory Oddball Responses Across the Schizophrenia-Bipolar Spectrum and Their Relationship to Cognitive and Clinical Features.The American journal of psychiatry · 2021Article
- Is a paired-stimuli configuration necessary to obtain typical evoked response differences in studies of psychosis? An MEG study.Biomarkers in neuropsychiatry · 2021Article
- Reduced influence of perceptual context in schizophrenia: behavioral and neurophysiological evidence.Psychological medicine · 2021Article
- Auditory paired-stimuli responses across the psychosis and bipolar spectrum and their relationship to clinical features.Biomarkers in neuropsychiatry · 2020Article
- fMRI evidence of aberrant neural adaptation for objects in schizophrenia and bipolar disorder.Human brain mapping · 2019Article
- Article
- Genetic correlates of the development of theta event related oscillations in adolescents and young adults.International journal of psychophysiology : official journal of the International Organization of Psychophysiology · 2017Article
- Prioritizing schizophrenia endophenotypes for future genetic studies: An example using data from the COGS-1 family study.Schizophrenia research · 2016Article
- Gender modulates the development of theta event related oscillations in adolescents and young adults.Behavioural brain research · 2015Article
- Event-related potential and time-frequency endophenotypes for schizophrenia and psychotic bipolar disorder.Biological psychiatry · 2015Article
- Family history of psychosis moderates early auditory cortical response abnormalities in non-psychotic bipolar disorder.Bipolar disorders · 2013Article
- Altered metabolites in the plasma of autism spectrum disorder: a capillary electrophoresis time-of-flight mass spectroscopy study.PloS one · 2013Article
Corrections and comments
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Authors and funding
5 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundThe utility of an endophenotype depends on its ability to reduce complex disorders into stable, genetically linked phenotypes. P50 and P300 event-related potential (ERP) measures are endophenotype candidates for schizophrenia; however, their abnormalities are broadly observed across neuropsychiatric disorders. This study examined the diagnostic efficiency of P50 and P300 in schizophrenia as compared with healthy and bipolar disorder samples. Supplemental ERP measures and a multivariate classification approach were evaluated as methods to improve specificity.
methodsDiagnostic classification was first modeled in schizophrenia (SZ = 50) and healthy normal (HN = 50) samples using hierarchical logistic regression with predictors blocked by 4 levels of analysis: (1) P50 suppression, P300 amplitude, and P300 latency; (2) N100 amplitude; (3) evoked spectral power; and (4) P50 and P300 hemispheric asymmetry. The optimal model was cross-validated in a holdout sample (SZ = 34, HN = 31) and tested against a bipolar (BP = 50) sample.
resultsP50 and P300 endophenotypes classified SZ from HN with 71% accuracy (sensitivity = .70, specificity = .72) but did not differentiate SZ from BP above chance level. N100 and spectral power measures improved classification accuracy of SZ vs HN to 79% (sensitivity = .78, specificity = .80) and SZ vs BP to 72% (sensitivity = .74, specificity = .70). Cross validation analyses supported the stability of these models.
conclusionsAlthough traditional P50 and P300 measures failed to differentiate schizophrenia from bipolar participants, N100 and evoked spectral power measures added unique variance to classification models and improved accuracy to nearly the same level achieved in comparison of schizophrenia to healthy individuals.
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