ArticleThe Journal of experimental medicine2012
Chemokine-dependent T cell migration requires aquaporin-3-mediated hydrogen peroxide uptake.
Article in The Journal of experimental medicine, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 116 papers.
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Who cites it
116 citing papers in PubMed.
- Glycerol enhances mitochondrial metabolism and inflammatory response in pro-inflammatory macrophages.EMBO reports · 2026Article
- AQP3 as a potential biomarker for caries.BMC oral health · 2026Observational
- Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds.Cell reports · 2026Article
- Biophysical modeling identifies an optimal hybrid amoeboid-mesenchymal mechanism for maximal T cell migration speeds.bioRxiv : the preprint server for biology · 2025Article
- Linking the production of reactive oxygen species to the expression of antimicrobial peptides through aquaporin in an arthropod.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
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- Article
- Selective Blockade of Two Aquaporin Channels, AQP3 and AQP9, Impairs Human Leukocyte Migration.Cells · 2025Article
- Surface CD69-Negative CD4 and CD8 Bone Marrow-Resident Human Memory T Cells.European journal of immunology · 2025Article
- Aquaporin 3 inhibition attenuates imiquimod-induced psoriatic symptoms in a murine model.Molecular biology reports · 2025Article
- MGST1 Protects Pancreatic Ductal Cells from Inflammatory Damage in Acute Pancreatitis by Inhibiting Ferroptosis: Bioinformatics Analysis with Experimental Validation.International journal of molecular sciences · 2025Article
- Exploring Aquaporins in Human Studies: Mechanisms and Therapeutic Potential in Critical Illness.Life (Basel, Switzerland) · 2024Review
- Balanced Duality: HInternational journal of molecular sciences · 2024Review
- Peroxiporins and Oxidative Stress: Promising Targets to Tackle Inflammation and Cancer.International journal of molecular sciences · 2024Review
- Review
- TCF1-LEF1 co-expression identifies a multipotent progenitor cell (TNature immunology · 2024Article
- Aquaporins (AQPs) as a marker in the physiology of inflammation and its interaction studies with garcinol.Inflammopharmacology · 2024Article
- Aquaporins in the Cornea.International journal of molecular sciences · 2024Review
- The architecture of redox microdomains: Cascading gradients and peroxiredoxins' redox-oligomeric coupling integrate redox signaling and antioxidant protection.Redox biology · 2024Article
- The Aquaporin 3 Polymorphism (rs17553719) Is Associated with Sepsis Survival and Correlated with IL-33 Secretion.International journal of molecular sciences · 2024Article
56 more citing papers are in PubMed but not listed here.
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Authors and funding
7 authors.
Funding
Abstract
Chemokine-dependent trafficking is indispensable for the effector function of antigen-experienced T cells during immune responses. In this study, we report that the water/glycerol channel aquaporin-3 (AQP3) is expressed on T cells and regulates their trafficking in cutaneous immune reactions. T cell migration toward chemokines is dependent on AQP3-mediated hydrogen peroxide (H(2)O(2)) uptake but not the canonical water/glycerol transport. AQP3-mediated H(2)O(2) transport is essential for the activation of the Rho family GTPase Cdc42 and the subsequent actin dynamics. Coincidentally, AQP3-deficient mice are defective in the development of hapten-induced contact hypersensitivity, which is attributed to the impaired trafficking of antigen-primed T cells to the hapten-challenged skin. We therefore suggest that AQP3-mediated H(2)O(2) uptake is required for chemokine-dependent T cell migration in sufficient immune response.
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