ArticleThe American journal of tropical medicine and hygiene2012
Use of fecal occult blood tests as epidemiologic indicators of morbidity associated with intestinal schistosomiasis during preventive chemotherapy in young children.
Article in The American journal of tropical medicine and hygiene, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Decline in infection-related morbidities following drug-mediated reductions in the intensity of Schistosoma infection: A systematic review and meta-analysis.PLoS neglected tropical diseases · 2017Pooled it
- Praziquantel for the treatment of schistosomiasis during human pregnancy.Bulletin of the World Health Organization · 2018Trial
- Multiplex Serologic Assessment of Schistosomiasis in Western Kenya: Antibody Responses in Preschool Aged Children as a Measure of Reduced Transmission.The American journal of tropical medicine and hygiene · 2017Trial
- Efficacy and safety of praziquantel for the treatment of human schistosomiasis during pregnancy: a phase 2, randomised, double-blind, placebo-controlled trial.The Lancet. Infectious diseases · 2016Trial
- Association between Schistosoma mansoni infection and fecal occult blood in schoolchildren in Mbita, Suba North sub-county, western Kenya.Tropical medicine and health · 2026Article
- Barriers and misconceptions hindering reduction of intestinal schistosomiasis in Mbita Sub-County, Western Kenya.Tropical medicine and health · 2024Article
- Experimental infection withParasitology · 2022Article
- Article
- Article
- Paediatric schistosomiasis: What we know and what we need to know.PLoS neglected tropical diseases · 2018Review
- Positive fecal occult blood test as a diagnostic cue forIDCases · 2017Article
- Morbidity associated with schistosomiasis before and after treatment in young children in Rusinga Island, western Kenya.The American journal of tropical medicine and hygiene · 2015Article
- Mapping of Schistosomiasis and Soil-Transmitted Helminths in Namibia: The First Large-Scale Protocol to Formally Include Rapid Diagnostic Tests.PLoS neglected tropical diseases · 2015Article
- Influence of Schistosoma mansoni and Hookworm Infection Intensities on Anaemia in Ugandan Villages.PLoS neglected tropical diseases · 2015Article
- Human schistosomiasis.Lancet (London, England) · 2014Review
- Schistosomiasis in pre-school-age children and their mothers in Chikhwawa district, Malawi with notes on characterization of schistosomes and snails.Parasites & vectors · 2014Article
- Fecal occult blood and fecal calprotectin as point-of-care markers of intestinal morbidity in Ugandan children with Schistosoma mansoni infection.PLoS neglected tropical diseases · 2013Article
- Schistosomiasis in African infants and preschool children: let them now be treated!Trends in parasitology · 2013Review
- Proposed morbidity markers amongTropical parasitologyArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
Abstract
There is a need for field-applicable markers to assess morbidity associated with intestinal schistosomiasis, especially in the context of preventive chemotherapy in young children. We investigated whether fecal occult blood (FOB) point-of-care tests could be used to assess intestinal pathology over a 12-month period in a cohort of 382 children (< 5 years of age). We found a strong association between egg-patent schistosomiasis and FOB at baseline (odds ratio [OR] = 3.1, P < 0.0001), 6 months (OR = 3.4, P < 0.0001), and 12 months (OR = 3.5, P < 0.0001), despite repeated chemotherapy. There were tendencies for prevalence of FOB to decrease in children who became egg negative and increase in those who became egg positive. Our results demonstrate overt disease in children less than five years of age. We therefore propose that FOB is useful for assessing dynamics of intestinal morbidity in young children at the community level and monitoring changes in morbidity after mass chemotherapy.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.