ArticleProceedings of the National Academy of Sciences of the United States of America2012
An injury-response mechanism conserved across kingdoms determines entry of the fungus Trichoderma atroviride into development.
Article in Proceedings of the National Academy of Sciences of the United States of America, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed, 113 citations in OpenAlex.
- Underlying the early signaling and gene expression of Pleurotus ostreatus mycelia during injury response.World journal of microbiology & biotechnology · 2025Article
- Exogenous dsRNA triggers sequence-specific RNAi and fungal stress responses to control Magnaporthe oryzae in Brachypodium distachyon.Communications biology · 2025Article
- Adaptative responses of Neurospora crassa by histidine kinases upon the attack of the arthropod Sinella curviseta.Current genetics · 2024Article
- Contrasting effects of NADPH oxidases on the fungal hyphae growth and immune responses inFrontiers in microbiology · 2024Article
- Uncovering the multifaceted properties of 6-pentyl-alpha-pyrone for control of plant pathogens.Frontiers in plant science · 2024Review
- Trichoderma: a multipurpose, plant-beneficial microorganism for eco-sustainable agriculture.Nature reviews. Microbiology · 2023Review
- A lectin gene is involved in the defense ofFrontiers in microbiology · 2023Article
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- Pseudo-Chromosomal Genome Assembly in Combination with Comprehensive Transcriptome Analysis inJournal of fungi (Basel, Switzerland) · 2022Article
- Circadian oscillations ineLife · 2022Article
- Catalases in the pathogenesis ofPeerJ · 2022Review
- Histidine kinase two-component response regulators Ssk1, Skn7 and Rim15 differentially control growth, developmental and volatile organic compounds emissions as stress responses in Trichoderma atroviride.Current research in microbial sciences · 2022Article
- Drosophila attack inhibits hyphal regeneration and defense mechanisms activation for the fungus Trichoderma atroviride.The ISME journal · 2022Article
- Comparative genomics reveals a core gene toolbox for lifestyle transitions in Hypocreales fungi.Environmental microbiology · 2021Article
- Surviving the odds: From perception to survival of fungal phytopathogens under host-generated oxidative burst.Plant communications · 2021Review
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- Transcriptome Dynamics Underlying Chlamydospore Formation inFrontiers in microbiology · 2021Article
- Functional characterization of the AGL1 aegerolysin in the mycoparasitic fungus Trichoderma atroviride reveals a role in conidiation and antagonism.Molecular genetics and genomics : MGG · 2021Article
- Fungal evolution: cellular, genomic and metabolic complexity.Biological reviews of the Cambridge Philosophical Society · 2020Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A conserved injury-defense mechanism is present in plants and animals, in which the production of reactive oxygen species (ROS) and lipid metabolism are essential to the response. Here, we describe that in the filamentous fungus Trichoderma atroviride, injury results in the formation of asexual reproduction structures restricted to regenerating cells. High-throughput RNA-seq analyses of the response to injury in T. atroviride suggested an oxidative response and activation of calcium-signaling pathways, as well as the participation of lipid metabolism, in this phenomenon. Gene-replacement experiments demonstrated that injury triggers NADPH oxidase (Nox)-dependent ROS production and that Nox1 and NoxR are essential for asexual development in response to damage. We further provide evidence of H(2)O(2) and oxylipin production that, as in plants and animals, may act as signal molecules in response to injury in fungi, suggesting that the three kingdoms share a conserved defense-response mechanism.
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