Evidence map›Paper›PMID 22926922›Full record

ArticleJournal of autism and developmental disorders2013

Can bronchoscopic airway anatomy be an indicator of autism?

Barbara A Stewart, Amar J S Klar

Abstract read
In one paragraph

Article in Journal of autism and developmental disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. Article
  6. Opposite Expression Patterns ofFrontiers in psychiatry · 2019
    Article
  7. Article
  8. δ ENaC: a novel divergent amiloride-inhibitable sodium channel.American journal of physiology. Lung cellular and molecular physiology · 2012
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Barbara A StewartPediatric Pulmonary Department, Children's Health Center, St. Joseph's Hospital and Medical Center, Phoenix, AZ 85013, USA. tinkdoc@cox.net
Amar J S Klar

Funding

STUDIES ON SILENCINGZ01BC010381 · NCI · DIVISION OF BASIC SCIENCES - NCI · PI KLAR, AMAR J · 2000 to 2008
$602k
Intramural NIH HHS Z01 BC010381
6 · The paper itself

Abstract

Bronchoscopic evaluations revealed that some children have double branching of bronchi (designated "doublets") in the lower lungs airways, rather than normal, single branching. Retrospective analyses revealed only one commonality in them: all subjects with doublets also had autism or autism spectrum disorder (ASD). That is, 49 subjects exhibited the presence of initial normal anatomy in upper airway followed by doublets in the lower airway. In contrast, the normal branching pattern was noted in all the remaining 410 subjects who did not have a diagnosis of autism/ASD. We propose that the presence of doublets might be an objective, reliable, and valid biologic marker of autism/ASD.

Indexed as

AdolescentBiomarkersBronchiBronchoscopyChildChild Development Disorders, PervasiveChild, PreschoolFemaleHumansMaleRetrospective StudiesBiomarkers

Identifiers

PMID22926922
PMCPMC6959546

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.