ArticleBioEssays : news and reviews in molecular, cellular and developmental biology2012
Whole chromosome aneuploidy: big mutations drive adaptation by phenotypic leap.
Article in BioEssays : news and reviews in molecular, cellular and developmental biology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 43 papers.
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Who cites it
43 citing papers in PubMed.
- ALFA-K: Local adaptive mapping of karyotype fitness landscapes.Nature communications · 2025Article
- Template switching during DNA replication is a prevalent source of adaptive gene amplification.eLife · 2025Article
- Template switching during DNA replication is a prevalent source of adaptive gene amplification.bioRxiv : the preprint server for biology · 2024Article
- Enhanced oxidative stress resistance in Ustilago maydis and its implications on the virulence.International microbiology : the official journal of the Spanish Society for Microbiology · 2024Article
- Aneuploidy Can Be an Evolutionary Diversion on the Path to Adaptation.Molecular biology and evolution · 2024Article
- Unveiling genome plasticity as a mechanism of non-antifungal-induced antifungal resistance inFrontiers in microbiology · 2024Article
- Ketoconazole induces reversible antifungal drug tolerance mediated by trisomy of chromosome R inFrontiers in microbiology · 2024Article
- Mitochondrial RNA methyltransferase TRMT61B is a new, potential biomarker and therapeutic target for highly aneuploid cancers.Cell death and differentiation · 2023Article
- Article
- Genomic Adaptations ofMicroorganisms · 2022Review
- The impact of monosomies, trisomies and segmental aneuploidies on chromosomal stability.PloS one · 2022Article
- Aneuploidy facilitates dysplastic and tumorigenic phenotypes in the Drosophila gut.Biology open · 2021Article
- Review
- Antifungal Drug Resistance: Molecular Mechanisms inChemical reviews · 2021Review
- P53 induces senescence in the unstable progeny of aneuploid cells.Cell cycle (Georgetown, Tex.) · 2020Article
- Genomic instability in an interspecific hybrid of the genusMicrobial genomics · 2020Article
- Molecular signatures of aneuploidy-driven adaptive evolution.Nature communications · 2020Article
- Improving Industrially Relevant Phenotypic Traits by Engineering Chromosome Copy Number inFrontiers in genetics · 2020Article
- Aneuploidy Enables Cross-Adaptation to Unrelated Drugs.Molecular biology and evolution · 2019Article
- Environmental stresses induce karyotypic instability in colorectal cancer cells.Molecular biology of the cell · 2019Article
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Authors and funding
3 authors.
Funding
Abstract
Despite its widespread existence, the adaptive role of aneuploidy (the abnormal state of having an unequal number of different chromosomes) has been a subject of debate. Cellular aneuploidy has been associated with enhanced resistance to stress, whereas on the organismal level it is detrimental to multicellular species. Certain aneuploid karyotypes are deleterious for specific environments, but karyotype diversity in a population potentiates adaptive evolution. To reconcile these paradoxical observations, this review distinguishes the role of aneuploidy in cellular versus organismal evolution. Further, it proposes a population genetics perspective to examine the behavior of aneuploidy on a populational versus individual level. By altering the copy number of a significant portion of the genome, aneuploidy introduces large phenotypic leaps that enable small cell populations to explore a wide phenotypic landscape, from which adaptive traits can be selected. The production of chromosome number variation can be further increased by stress- or mutation-induced chromosomal instability, fueling rapid cellular adaptation.
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Registered trials
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