ArticleChimerism
Predictors of male microchimerism.
Article in Chimerism. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
9 citing papers in PubMed.
- Identifying Key Questions and Challenges in Microchimerism Biology.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Sex, male origin microchimerism, and mortality in a Danish cohort.European journal of epidemiology · 2025Article
- The when, what, and where of naturally-acquired microchimerism.Seminars in immunopathology · 2025Review
- Male origin microchimerism and brain cancer: a case-cohort study.Journal of cancer research and clinical oncology · 2023Article
- Grandmaternal cells in cord blood.EBioMedicine · 2021Article
- Fetal microchimerism and implications for maternal health.Obstetric medicine · 2020Review
- Fetal microchimerism by mode of delivery: a prospective cohort study.BJOG : an international journal of obstetrics and gynaecology · 2019Article
- Statistical Methods for Unusual Count Data: Examples From Studies of Microchimerism.American journal of epidemiology · 2016Article
- Microchimerism of male origin in a cohort of Danish girls.Chimerism · 2015Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
The association between microchimerism acquired primarily through pregnancy and later disease is of increasing scientific interest. Because this line of research is new and little is known about the nature of microchimerism, studies of microchimerism are potentially vulnerable to error from confounding and reverse causation. To address the issue of confounding, we conducted an analysis of predictors of male microchimerism in 272 female participants of the Danish Diet, Cancer and Health cohort. Buffy coat DNA was tested for Y chromosome presence as a marker of male microchimerism. First, we used logistic regression and thereafter random forest modeling to evaluate the ability of a range of reproductive, lifestyle, hospital or clinic visit history, and other variables to predict whether women tested positive for male microchimerism. We found some indication that current use of contraceptive pills and hormone replacement therapy reduced the odds of testing positive for male microchimerism. However, prediction of male microchimerism presence was poor based on the available variables. Studies of the possible role of male microchimerism in maternal health and disease are therefore unlikely to be heavily confounded by the variables examined in the present investigation. More research focused on acquisition, retention and clearing of male cells in the maternal circulation is needed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.