ArticleEuropean journal of nuclear medicine and molecular imaging2012
Diagnostic value of combined ¹⁸F-FDG PET/MRI for staging and restaging in paediatric oncology.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 1 of them a synthesis that pooled it.
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Who cites it
16 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Diagnostic Performance of Whole-Body PET/MRI for Detecting Malignancies in Cancer Patients: A Meta-Analysis.PloS one · 2016Pooled it
- Integrated whole-body PET/MRI with 18F-FDG, 18F-FDOPA, and 18F-FDA in paragangliomas in comparison with PET/CT: NIH first clinical experience with a single-injection, dual-modality imaging protocol.Clinical nuclear medicine · 2014Trial
- Positron Emission Tomography-Magnetic Resonance Imaging, a New Hybrid Imaging Modality for Dentomaxillofacial Malignancies-A Systematic Review.Diagnostics (Basel, Switzerland) · 2025Review
- Clinical utilization of whole-body PET/MRI in childhood sarcoma.Pediatric radiology · 2021Article
- Microstrip Transmission Line RF Coil for a PET/MRI Insert.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2020Article
- Imaging of primary pediatric lymphoma of bone.Pediatric radiology · 2016Article
- [Simultaneous whole-body PET-MRI in pediatric oncology : More than just reducing radiation?].Der Radiologe · 2016Review
- Quantitative multimodality imaging in cancer research and therapy.Nature reviews. Clinical oncology · 2014Review
- Usefulness of Integrated PET/MRI in Head and Neck Cancer: A Preliminary Study.Nuclear medicine and molecular imaging · 2014Article
- Prognostic imaging of neuroblastoma.European journal of nuclear medicine and molecular imaging · 2014Article
- PET/MRI and PET/CT in follow-up of head and neck cancer patients.European journal of nuclear medicine and molecular imaging · 2014Article
- Clinical oncologic applications of PET/MRI: a new horizon.American journal of nuclear medicine and molecular imaging · 2014Review
- Does the novel integrated PET/MRI offer the same diagnostic performance as PET/CT for oncological indications?PloS one · 2014Article
- Competitive advantage of PET/MRI.European journal of radiology · 2014Review
- MR-PET of the body: Early experience and insights.European journal of radiology open · 2014Review
- Comparison of (18)F-FDG PET/CT and (99 m)Tc-MDP bone scintigraphy for detection of bone metastasis in osteosarcoma.Skeletal radiology · 2013Article
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7 authors.
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No grant is acknowledged in the PubMed record.
Abstract
purposeThe present study compares the diagnostic value of (18)F-fluorodeoxyglucose (FDG) positron emission tomography (PET) and MRI to combined/registered (18)F-FDG PET/MRI for staging and restaging in paediatric oncology.
methodsOver 8 years and 2 months, 270 (18)F-FDG PET and 270 MRI examinations (mean interval 5 days) were performed in 132 patients with proven (n = 117) or suspected (n = 15) malignant disease: solid tumours (n = 64), systemic malignancy (n = 53) and benign disease (n = 15). A total of 259 suspected tumour lesions were analysed retrospectively during primary diagnosis and 554 lesions during follow-up. Image analysis was performed separately on each modality, followed by analysis of combined and registered (18)F-FDG PET/MRI imaging.
resultsA total of 813 lesions were evaluated and confirmed by histopathology (n = 158) and/or imaging follow-up (n = 655) after 6 months. In the separate analysis of (18)F-FDG PET and MRI, sensitivity was 86 %/94 % and specificity 85 %/38 %. Combined/registered (18)F-FDG PET/MRI led to a sensitivity of 97 %/97 % and specificity of 81 %/82 %. False-positive results ((18)F-FDG PET n = 69, MRI n = 281, combined (18)F-FDG PET/MRI n = 85, registered (18)F-FDG PET/MRI n = 80) were due to physiological uptake or post-therapeutic changes. False-negative results ((18)F-FDG PET n = 50, MRI n = 20, combined (18)F-FDG PET/MRI n = 11, registered (18)F-FDG PET/MRI n = 11) were based on low uptake or minimal morphological changes. Examination-based evaluation during follow-up showed a sensitivity/specificity of 91 %/81 % for (18)F-FDG PET, 93 %/30 % for MRI and 96 %/72 % for combined (18)F-FDG PET/MRI.
conclusionFor the detection of single tumour lesions, registered (18)F-FDG PET/MRI proved to be the methodology of choice for adequate tumour staging. In the examination-based evaluation, MRI alone performed better than (18)F-FDG PET and combined/registered imaging during primary diagnosis. At follow-up, however, the examination-based evaluation demonstrated a superiority of (18)F-FDG PET alone.
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