ArticleEuropean journal of nuclear medicine and molecular imaging2012
Hypodense regions in unenhanced CT identify nonviable myocardium: validation versus 18F-FDG PET.
Article in European journal of nuclear medicine and molecular imaging, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
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Who cites it
5 citing papers in PubMed.
- Intravenous regular insulin is an efficient and safe procedure for obtaining high-quality cardiacJournal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2022Trial
- Silent myocardial infarction fatty scars detected by coronary calcium score CT scan in diabetic patients without history of coronary heart disease.European radiology · 2024Article
- Value of 12-lead electrocardiogram to predict myocardial scar on FDG PET in heart failure patients.Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2021Article
- Artifact-free quantitative cardiovascular PET/MR imaging: An impossible dream?Journal of nuclear cardiology : official publication of the American Society of Nuclear Cardiology · 2019Article
- Myocardial perfusion imaging with cardiac computed tomography: state of the art.Journal of cardiovascular translational research · 2013Review
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Authors and funding
9 authors.
Funding
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Abstract
purposeThe aim of the present study was to evaluate the accuracy of hypodense regions in non-contrast-enhanced cardiac computed tomography (unenhanced CT) to identify nonviable myocardial scar tissue.
methodsHypodense areas were visually identified in unenhanced CT of 80 patients in the left ventricular anterior, apical, septal, lateral and inferior myocardium and CT density was measured in Hounsfield units (HU). Findings were compared to (18)F-fluorodeoxyglucose uptake by positron emission tomography (FDG PET), which served as the standard of reference to distinguish scar (<50 % FDG uptake) from viable tissue (≥50 % uptake).
resultsVisually detected hypodense regions demonstrated a sensitivity, specificity, positive predictive value (PPV) and negative predictive value (NPV) of 74, 97, 84 and 94 %, respectively. A receiver-operating characteristic (ROC) curve analysis revealed a cutoff value of mean HU at <28.8 for predicting scar tissue with an area under the curve of 0.93 yielding a sensitivity, specificity, PPV and NPV of 94, 90, 67 and 99 %, respectively.
conclusionHypodense regions in unenhanced cardiac CT scans allow accurate identification of nonviable myocardial scar tissue.
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