ArticleSeminars in immunopathology2012
Food-induced anaphylaxis: mast cells as modulators of anaphylactic severity.
Article in Seminars in immunopathology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed.
- S. aureus exposure during cutaneous antigen sensitization causes basophil- and interleukin-4-dependent exaggerated food anaphylaxis.Immunity · 2025Article
- Article
- Ethanol Extract ofAdvances in pharmacological and pharmaceutical sciences · 2024Article
- The Hdc GC box is critical for Hdc gene transcription and histamine-mediated anaphylaxis.The Journal of allergy and clinical immunology · 2023Article
- Development of gastro-food allergy model in shrimp allergen extract-induced sensitized mice promotes mast cell degranulation.Journal of public health in Africa · 2023Article
- ELK4 exerts opposite roles in cytokine/chemokine production and degranulation in activated mast cells.Frontiers in immunology · 2023Article
- Allergen-Specific IgA Antibodies Block IgE-Mediated Activation of Mast Cells and Basophils.Frontiers in immunology · 2022Article
- Perturbations to Homeostasis in Experimental Models Revealed Innate Pathways Driving Food Allergy.Frontiers in immunology · 2020Review
- Immunomodulatory effects of breast milk on food allergy.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2019Review
- Avenanthramide C from germinated oats exhibits anti-allergic inflammatory effects in mast cells.Scientific reports · 2019Article
- The soluble isoform of human FcɛRI is an endogenous inhibitor of IgE-mediated mast cell responses.Allergy · 2019Article
- Deletion of ΔdblGata motif leads to increased predisposition and severity of IgE-mediated food-induced anaphylaxis response.PloS one · 2019Article
- Gomisin M2 Inhibits Mast Cell-Mediated Allergic InflammationFrontiers in pharmacology · 2019Article
- The transcription factors GATA2 and microphthalmia-associated transcription factor regulate Hdc gene expression in mast cells and are required for IgE/mast cell-mediated anaphylaxis.The Journal of allergy and clinical immunology · 2018Article
- IgE promotes type 2 innate lymphoid cells in murine food allergy.Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology · 2018Article
- Molecular Regulation of Histamine Synthesis.Frontiers in immunology · 2018Review
- Article
- IL-33 promotes food anaphylaxis in epicutaneously sensitized mice by targeting mast cells.The Journal of allergy and clinical immunology · 2016Article
- FOXP3+ Tregs require WASP to restrain Th2-mediated food allergy.The Journal of clinical investigation · 2016Article
- Potential effector and immunoregulatory functions of mast cells in mucosal immunity.Mucosal immunology · 2015Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
Abstract
A food-induced anaphylactic reaction can occur within seconds to a few hours following exposure to the causal food allergen and often affects multiple organ systems including gastrointestinal, cutaneous, respiratory, and cardiovascular. A conundrum in the allergy field is that consumption of the same allergen can cause reactions of vastly different severity in separate individuals; one patient may experience a mild non-life-threatening reaction characterized by pruritis of lips or urticaria whereas another may experience a life-threatening reaction that involves respiratory and cardiovascular compromise leading to loss of consciousness and sometimes death. While there are tests available to determine the predictive risk value of a positive food challenge test or clinical reactivity, there is currently no reliable method to distinguish between individuals who are at risk of mild non-life-threatening versus life-threatening reaction. Recent research has significantly advanced our understanding of the involvement of immune pathways in the effector phase of food-induced anaphylaxis; a void remains regarding our understanding of the contribution of these pathways to severity of disease. In this review, we discuss mild non-life-threatening versus life-threatening food-induced anaphylaxis and factors (co-morbidities and immune activation) that predispose individuals to more severe disease. Furthermore, we summarize recent advancements in our understanding of the involvement of underlying immune pathways in systemic and food-induced anaphylaxis in mouse systems and discuss how these pathways may contribute to more severe disease phenotype.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.