ArticleClinical & experimental metastasis2012
Should ACOSOG Z0011 change practice with respect to axillary lymph node dissection for a positive sentinel lymph node biopsy in breast cancer?
Article in Clinical & experimental metastasis, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 64 citations in OpenAlex.
- Trial
- Impact of the ACOSOG Z0011 trial on surgical practice in Asian patients: trends in axillary surgery for breast cancer from a Korean Breast Cancer Registry analysis.World journal of surgical oncology · 2022Article
- Article
- Evolving Trends in Surgical Management of Breast Cancer: An Analysis of 30 Years of Practice Changing Papers.Frontiers in oncology · 2021Review
- Shortcomings of ultrasound-guided fine needle aspiration in the axillary management of women with breast cancer.World journal of surgical oncology · 2019Article
- AGO Recommendations for the Diagnosis and Treatment of Patients with Early Breast Cancer: Update 2019.Breast care (Basel, Switzerland) · 2019Review
- Predictive Factors for Non-Sentinel Lymph Node Metastasis in Patients with ACOSOG Z0011 Criteria.Breast care (Basel, Switzerland) · 2018Article
- Digital breast volume estimation (DBVE)-A new technique.The British journal of radiology · 2018Article
- Clinical risk analysis of non-visualized sentinel lymph node in breast cancer.Cancer biomarkers : section A of Disease markers · 2018Article
- Personalized axillary dissection: the number of excised lymph nodes of nodal-positive breast cancer patients has no significant impact on relapse-free and overall survival.Journal of cancer research and clinical oncology · 2017Article
- Impact of American College of Surgeons Oncology Group Z11 on surgical training at an academic cancer center.The Journal of surgical research · 2016Article
- Management of the axilla: has Z0011 had an impact?Irish journal of medical science · 2016Article
- Factors Influencing Non-sentinel Node Involvement in Sentinel Node Positive Patients and Validation of MSKCC Nomogram in Indian Breast Cancer Population.Indian journal of surgical oncology · 2015Article
- Role of Combined Sentinel Lymph Node Biopsy and Axillary Node Sampling in Clinically Node-Negative Breast Cancer.The Indian journal of surgery · 2015Article
- Evaluation of lymph node status after neoadjuvant chemotherapy in breast cancer patients: comparison of diagnostic performance of ultrasound, MRI and ¹⁸F-FDG PET/CT.The British journal of radiology · 2015Article
- Article
- Axillary dissection can be avoided in the majority of clinically node-negative patients undergoing breast-conserving therapy.Annals of surgical oncology · 2014Article
- Does our better understanding of breast cancer also improve the way we treat it?Gland surgery · 2013Article
- Breast cancer and sentinel lymph node micrometastases: indications for lymphadenectomy and literature review.Il Giornale di chirurgiaReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
While any study can be criticized, the results of Z0011 clearly show that sentinel lymph node biopsy (SLNB) alone without axillary lymph node dissection (ALND) results in extremely low locoregional recurrence and excellent overall survival comparable to completion ALND. The observed results in this trial with SLNB alone were excellent. A prospective randomized study with results such as Z0011 should alter therapy. The skilled clinician must utilize his or her experience and the prospective randomized data of this study to improve patient care for women with breast cancer. On the other hand, ALND continues to be the standard of care for positive nodes in the axilla, with lymph node status as the most important prognostic indicator in overall survival (OS) and disease-free survival (DFS) in the management of early stage breast cancer. The advent of sentinel lymph node resection (SLNR) is challenging this notion. There is evidence to support the need for regional control of the axilla as a preventative means for locoregional recurrence and improvement in DFS. ALND is both a diagnostic and therapeutic approach that not only decreases rates of locoregional recurrence, but also guides further treatment strategies. Currently, there are no definable criteria that completely prevent patients from benefiting from ALND in the setting of metastatic disease to the axilla. It is, therefore, clear that ALND should be strongly considered in the management of the SLN-positive axilla. SLNR has its role in the management of early stage breast cancer, but whether SLNR alone should replace ALND is yet to be determined.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.