Trial reportCancer prevention research (Philadelphia, Pa.)2012
A pilot study of low-cost, high-resolution microendoscopy as a tool for identifying women with cervical precancer.
Trial report in Cancer prevention research (Philadelphia, Pa.), 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04472455 (Mobile High-Resolution Microendoscopy), which is not on this map. Cited by 42 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Mobile High-Resolution Microendoscopy (mHRME) for the Detection of Cervical Dysplasia in El Salvador
Who cites it
42 citing papers in PubMed, 63 citations in OpenAlex.
- Cervical lesion assessment using real-time microendoscopy image analysis in Brazil: The CLARA study.International journal of cancer · 2021Trial
- Trial
- Diagnosing Cervical Neoplasia in Rural Brazil Using a Mobile Van Equipped withCancer prevention research (Philadelphia, Pa.) · 2018Trial
- Feasibility of clinical detection of cervical dysplasia using angle-resolved low coherence interferometry measurements of depth-resolved nuclear morphology.International journal of cancer · 2017Trial
- Evaluation of the Diagnostic Accuracy of Cervical Cell Morphologies from Android Device-Captured Cytopathological Microscopic Images through Artificial Intelligence in Mainly Rural or Resource-Constraint Areas of India.Asian Pacific journal of cancer prevention : APJCP · 2026Article
- Usability of a smartphone-compatible, confocal micro-endoscope for cervical cancer screening in resource-limited settings.BMC women's health · 2024Article
- Optical imaging for early detection of cervical cancer: state of the art and perspectives.Journal of biomedical optics · 2023Review
- Development of a multimodal mobile colposcope for real-time cervical cancer detection.Biomedical optics express · 2022Article
- Multi-task network for automated analysis of high-resolution endomicroscopy images to detect cervical precancer and cancer.Computerized medical imaging and graphics : the official journal of the Computerized Medical Imaging Society · 2022Article
- PARP1: A Potential Molecular Marker to Identify Cancer During Colposcopy Procedures.Journal of nuclear medicine : official publication, Society of Nuclear Medicine · 2021Article
- Cervical cancer prevention in El Salvador: A prospective evaluation of screening and triage strategies incorporating high-resolution microendoscopy to detect cervical precancer.International journal of cancer · 2021Article
- Reduced motion artifacts and speed improvements in enhanced line-scanning fiber bundle endomicroscopy.Journal of biomedical optics · 2021Article
- A Compact High-Speed Image-Based Method for Measuring the Longitudinal Motion of Living Tissues.Sensors (Basel, Switzerland) · 2020Article
- Label-free, High-Resolution Optical Metabolic Imaging of Human Cervical Precancers Reveals Potential for Intraepithelial Neoplasia Diagnosis.Cell reports. Medicine · 2020Article
- Development of Low-Cost Point-of-Care Technologies for Cervical Cancer Prevention Based on a Single-Board Computer.IEEE journal of translational engineering in health and medicine · 2020Article
- In vivo imaging of cervical precancer using a low-cost and easy-to-use confocal microendoscope.Biomedical optics express · 2020Article
- A Dual-modality Smartphone Microendoscope for Quantifying the Physiological and Morphological Properties of Epithelial Tissues.Scientific reports · 2019Article
- Low-cost, high-resolution imaging for detecting cervical precancer in medically-underserved areas of Texas.Gynecologic oncology · 2019Article
- Article
- Fiber bundle shifting endomicroscopy for high-resolution imaging.Biomedical optics express · 2018Article
Corrections and comments
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Authors and funding
8 authors at 5 institutions in 2 countries.
Funding
Abstract
Cervical cancer remains one of the leading causes of death among women in developing countries. Without resources to support Pap smear cytology and colposcopy, cost-effective approaches which enable single-visit "see-and-treat" protocols offer the potential to reduce morbidity and mortality due to this preventable disease. We carried out a pilot clinical study in Shanxi province, China, to evaluate a low-cost, high-resolution microendoscope (HRME) imaging system which enables evaluation of epithelial cell morphology in vivo. HRME images were obtained at discrete sites on the cervix in 174 women, in addition to visual inspection with acetic acid (VIA) and colposcopic examination. Of 69 sites appearing abnormal on colposcopy, only 12 showed high-grade disease (CIN2+) on pathology. Quantification of the nuclear-to-cytoplasm ratio by HRME enabled an ad hoc threshold to be defined, which correctly classified all 12 sites as abnormal, whilst classifying 38 of the remaining 57 pathology normal sites as normal. All patients with biopsy confirmed high-grade disease also tested positive for high-risk human papilloma virus (HPV) DNA and were classified as abnormal by HRME. Among the remaining patients who tested positive for HPV but were either normal by colposcopy or showed <CIN2 on pathology, only 6 of 32 (18.8%) were classified as abnormal by HRME. Visual examination techniques for cervical cancer screening may overestimate the prevalence of precancerous lesions, leading to unnecessary treatment, expense, and patient stress. The results of this study suggest that evaluation of suspicious lesions by HRME may assist in ruling out immediate cryotherapy, thus increasing the efficiency of current see-and-treat programs.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.