ReviewAdvanced drug delivery reviews2012
MEMS-enabled implantable drug infusion pumps for laboratory animal research, preclinical, and clinical applications.
Review in Advanced drug delivery reviews, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
22 citing papers in PubMed, 82 citations in OpenAlex.
- Biomimetic rhythm programming and intelligent delivery: The BRIGHT transdermal patch revolutionizes chronotherapy for growth hormone treatment.Biomaterials translational · 2025Article
- Comprehensive Therapeutic Approaches to Tuberculous Meningitis: Pharmacokinetics, Combined Dosing, and Advanced Intrathecal Therapies.Pharmaceutics · 2024Review
- Preparation of PLGA Microspheres Using the Non-Toxic Glycofurol as Polymer Solvent by a Modified Phase Inversion Methodology.Polymers · 2024Article
- Intracalvariosseous administration of donepezil microspheres protects against cognitive impairment by virtue of long-lasting brain exposure in mice.Theranostics · 2024Article
- Smart Sensors and Microtechnologies in the Precision Medicine Approach against Lung Cancer.Pharmaceuticals (Basel, Switzerland) · 2023Review
- A pH-Responsive Asymmetric Microfluidic/Chitosan Device for Drug Release in Infective Bone Defect Treatment.International journal of molecular sciences · 2023Article
- Modeling programmable drug delivery in bioelectronics with electrochemical actuation.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Recent advances in bioelectronics chemistry.Chemical Society reviews · 2020Review
- Recent Advances in Micro-Electro-Mechanical Devices for Controlled Drug Release Applications.Frontiers in bioengineering and biotechnology · 2020Review
- Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Battery-free, fully implantable optofluidic cuff system for wireless optogenetic and pharmacological neuromodulation of peripheral nerves.Science advances · 2019Article
- Advanced implantable drug delivery technologies: transforming the clinical landscape of therapeutics for chronic diseases.Biomedical microdevices · 2019Review
- An investigation into closed-loop treatment of neurological disorders based on sensing mitochondrial dysfunction.Journal of neuroengineering and rehabilitation · 2018Review
- Implantable batteryless device for on-demand and pulsatile insulin administration.Nature communications · 2017Article
- Research Update: Materials design of implantable nanogenerators for biomechanical energy harvesting.APL materials · 2017Article
- Prevascularized silicon membranes for the enhancement of transport to implanted medical devices.Journal of biomedical materials research. Part B, Applied biomaterials · 2016Article
- Microfabrication for Drug Delivery.Materials (Basel, Switzerland) · 2016Review
- A Wireless Implantable Micropump for Chronic Drug Infusion Against Cancer.Sensors and actuators. A, Physical · 2016Article
- Acceleration Techniques for Recombination of Gases in Electrolysis Microactuators with Nafion®-Coated Electrocatalyst.Sensors and actuators. B, Chemical · 2015Article
- A remotely operated drug delivery system with an electrolytic pump and a thermo-responsive valve.Biomicrofluidics · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Innovation in implantable drug delivery devices is needed for novel pharmaceutical compounds such as certain biologics, gene therapy, and other small molecules that are not suitable for administration by oral, topical, or intravenous routes. This invasive dosing scheme seeks to directly bypass physiological barriers presented by the human body, release the appropriate drug amount at the site of treatment, and maintain the drug bioavailability for the required duration of administration to achieve drug efficacy. Advances in microtechnologies have led to novel MEMS-enabled implantable drug infusion pumps with unique performance and feature sets. In vivo demonstration of micropumps for laboratory animal research and preclinical studies include acute rapid radiolabeling, short-term delivery of nanomedicine for cancer treatment, and chronic ocular drug dosing. Investigation of MEMS actuators, valves, and other microstructures for on-demand dosing control may enable next generation implantable pumps with high performance within a miniaturized form factor for clinical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.