ArticleMammalian genome : official journal of the International Mammalian Genome Society2012
Beyond knockouts: cre resources for conditional mutagenesis.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 38 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
38 citing papers in PubMed.
- Systematic optimization and prediction of cre recombinase for precise genome editing in mice.Genome biology · 2025Article
- iSuRe-HadCre is an essential tool for effective conditional genetics.Nucleic acids research · 2024Article
- Large-Scale Genome-Wide Optimization and Prediction of the Cre Recombinase System for Precise Genome Manipulation in Mice.Research square · 2024Article
- Large-Scale Genome-Wide Optimization and Prediction of the Cre Recombinase System for Precise Genome Manipulation in Mice.bioRxiv : the preprint server for biology · 2024Article
- Microglial-specific knockdown of iron import gene, Slc11a2, blunts LPS-induced neuroinflammatory responses in a sex-specific manner.Brain, behavior, and immunity · 2024Article
- Pairing of single mutations yields obligate Cre-type site-specific recombinases.Nucleic acids research · 2022Article
- AAV-Molecular therapy. Methods & clinical development · 2021Article
- Article
- Article
- Principles of Genetic Engineering.Genes · 2020Review
- Genetic Tools to Study Cardiovascular Biology.Frontiers in physiology · 2020Review
- iSuRe-Cre is a genetic tool to reliably induce and report Cre-dependent genetic modifications.Nature communications · 2019Article
- Article
- Functional Access to Neuron Subclasses in Rodent and Primate Forebrain.Cell reports · 2019Article
- Large-scale discovery of mouse transgenic integration sites reveals frequent structural variation and insertional mutagenesis.Genome research · 2019Article
- Lineage Tracing: Computational Reconstruction Goes Beyond the Limit of Imaging.Molecules and cells · 2019Review
- Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target genes.Laboratory animal research · 2018Review
- Article
- Mouse Genome Informatics (MGI) Resource: Genetic, Genomic, and Biological Knowledgebase for the Laboratory Mouse.ILAR journal · 2017Review
- Next-generation mammalian genetics toward organism-level systems biology.NPJ systems biology and applications · 2017Review
Corrections and comments
- Erratum issued
Authors and funding
5 authors.
Funding
Abstract
With the effort of the International Phenotyping Consortium to produce thousands of strains with conditional potential gathering steam, there is growing recognition that it must be supported by a rich toolbox of cre driver strains. The approaches to build cre strains have evolved in both sophistication and reliability, replacing first-generation strains with tools that can target individual cell populations with incredible precision and specificity. The modest set of cre drivers generated by individual labs over the past 15+ years is now growing rapidly, thanks to a number of large-scale projects to produce new cre strains for the community. The power of this growing resource, however, depends upon the proper deep characterization of strain function, as even the best designed strain can display a variety of undesirable features that must be considered in experimental design. This must be coupled with the parallel development of informatics tools to provide functional data to the user and facilitated access to the strains through public repositories. We discuss the current progress on all of these fronts and the challenges that remain to ensure the scientific community can capitalize on the tremendous number of mouse resources at their disposal.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.