ArticleMolecular and cellular neurosciences2012
Uncoupling stimulus specificity and glomerular position in the mouse olfactory system.
Article in Molecular and cellular neurosciences, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers.
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Who cites it
28 citing papers in PubMed, 35 citations in OpenAlex.
- Rapid temporal processing in the olfactory bulb underlies concentration-invariant odor identification and signal decorrelation.Nature neuroscience · 2026Article
- A microbiome-derived olfactory signal regulates inter-male aggression and social dominance in mice.Current biology : CB · 2026Article
- The neurexin gene family regulates olfactory glomerular formation.Cell reports · 2025Article
- A common mechanism of singular gene choice is revealed by broadly expressed odorant receptor transgenes within the olfactory epithelium.Cell reports · 2025Article
- Immature olfactory sensory neurons provide behaviourally relevant sensory input to the olfactory bulb.Nature communications · 2022Article
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- Low signaling efficiency from receptor to effector in olfactory transduction: A quantified ligand-triggered GPCR pathway.Proceedings of the National Academy of Sciences of the United States of America · 2022Article
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- Conserved C-terminal motifs in odorant receptors instruct their cell surface expression and cAMP signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2021Article
- Manipulating synthetic optogenetic odors reveals the coding logic of olfactory perception.Science (New York, N.Y.) · 2020Article
- Loss of odor-induced c-Fos expression of juxtaglomerular activity following maintenance of mice on fatty diets.Journal of bioenergetics and biomembranes · 2019Article
- Vapor detection and discrimination with a panel of odorant receptors.Nature communications · 2018Article
- Sparsened neuronal activity in an optogenetically activated olfactory glomerulus.Scientific reports · 2018Article
- Stimulus dependent diversity and stereotypy in the output of an olfactory functional unit.Nature communications · 2018Article
- IGF1-Dependent Synaptic Plasticity of Mitral Cells in Olfactory Memory during Social Learning.Neuron · 2017Article
- Postnatal Odor Exposure Increases the Strength of Interglomerular Lateral Inhibition onto Olfactory Bulb Tufted Cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Early Odorant Exposure Increases the Number of Mitral and Tufted Cells Associated with a Single Glomerulus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The Odorant Receptor-Dependent Role of Olfactory Marker Protein in Olfactory Receptor Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- The extremely broad odorant response profile of mouse olfactory sensory neurons expressing the odorant receptor MOR256-17 includes trace amine-associated receptor ligands.The European journal of neuroscience · 2016Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
Sensory information is often mapped systematically in the brain with neighboring neurons responding to similar stimulus features. The olfactory system represents chemical information as spatial and temporal activity patterns across glomeruli in the olfactory bulb. However, the degree to which chemical features are mapped systematically in the glomerular array has remained controversial. Here, we test the hypothesis that the dual roles of odorant receptors, in axon guidance and odor detection, can serve as a mechanism to map olfactory inputs with respect to their function. We compared the relationship between response specificity and glomerular position in genetically-defined olfactory sensory neurons expressing variant odorant receptors. We find that sensory neurons with the same odor response profile can be mapped to different regions of the bulb, and that neurons with different response profiles can be mapped to the same glomeruli. Our data demonstrate that the two functions of odorant receptors can be uncoupled, indicating that the mechanisms that map olfactory sensory inputs to glomeruli do so without regard to stimulus specificity.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.