ArticleEuropean radiology2012
Differences in the location and activity of intestinal Crohn's disease lesions between adult and paediatric patients detected with MRI.
Article in European radiology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 2 of them syntheses that pooled it.
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Who cites it
11 citing papers in PubMed, 2 syntheses or guidelines pooled it, 27 citations in OpenAlex.
- Saudi consensus guidance for the diagnosis and management of inflammatory bowel disease in children and adolescents.Saudi journal of gastroenterology : official journal of the Saudi Gastroenterology Association · 2025Guideline
- Pooled it
- A review of magnetic resonance enterography based Crohn's disease activity indices in paediatric patients.Przeglad gastroenterologiczny · 2022Review
- MRI reveals different Crohn's disease phenotypes in children and adults.European radiology · 2019Article
- Assessment of patency capsule retention using MR diffusion-weighted imaging.European radiology · 2017Article
- Colonic inflammation in pediatric inflammatory bowel disease: detection with magnetic resonance enterography.Pediatric radiology · 2017Article
- Interleukin 34: a new modulator of human and experimental inflammatory bowel disease.Clinical science (London, England : 1979) · 2015Article
- Use of Imaging Techniques in Inflammatory Bowel Diseases That Minimize Radiation Exposure.Current gastroenterology reports · 2015Review
- Surgical strategies in paediatric inflammatory bowel disease.World journal of gastroenterology · 2015Review
- Ultrasonographic imaging of inflammatory bowel disease in pediatric patients.World journal of gastroenterology · 2015Review
- Inflammatory bowel disease-the role of cross-sectional imaging techniques in the investigation of the small bowel.Insights into imaging · 2015Article
Corrections and comments
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo prospectively compare paediatric patients (PP) and adult patients (AP) affected by Crohn's disease (CD) in terms of the location and activity of intestinal lesions.
methodsForty-three children (mean age 15 years) and 43 adults (mean age 48 years) with proven CD underwent magnetic resonance enterography (MRE) to localise lesions and detect their activity in 9 segments of the small and large bowel. The results were analysed on a per patient and per segment basis. Ileo-colonoscopy was performed in all patients. P values less than 0.05 were considered statistically significant.
resultsInvolvement of terminal ileum was significantly different in the two groups: observed in 100 % of AP (43/43) versus 58 % (23/43) of PP (P < 0.0001). Conversely, the colon was diseased in 84 % of PP versus 64 % of AP. In particular, left colonic segments were significantly more involved in PP (descending colon 53 % versus 21 %, P < 0.01; rectum 67 % versus 23 %, P < 0.0001; sigmoid colon 56 % versus 37 %, not significant), whereas caecal involvement was equal in both groups. In children the maximal disease activity was found in left colonic segments, whereas in adults it was in the terminal ileum.
conclusionsMRE detected significant differences between the two populations, showing a more extensive and severe involvement of the left colon in children but the distal ileum in adults. KEY POINTS : • MRI is useful for assessing Crohn's disease in adult and paediatric patients. • Adult and paediatric patients show different intestinal involvement on MRI. • The distal ileum is maximally involved in adults vs. the left colon in children. • The causes of the severe left colonic disease in children are unknown. • The extensive colonic involvement in children has clinical-diagnostic implications.
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