Evidence map›Paper›PMID 22925832›Full record

Trial reportMolecular psychiatry2013

Pro-inflammatory cytokines as predictors of antidepressant effects of exercise in major depressive disorder.

C D Rethorst, M S Toups, T L Greer, P A Nakonezny, T J Carmody, B D Grannemann, R M Huebinger, R C Barber, M H Trivedi

Registry-linked trialOpen access · greenAbstract readComparative StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Molecular psychiatry, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06073340 (Observational Longitudinal Study of Individuals With Stimulant Use Disorder), which is not on this map. Cited by 93 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
93citing papers in PubMed, 4 pooled it
3.8field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06073340 terminatednot on this mapstarted 2023, after this paper: background citation

Observational Longitudinal Study of Individuals With Stimulant Use Disorder: Research and Development of a Biosignature

TypeobservationalSponsorUniversity of Texas Southwestern Medical CenterRan2023 to 2025Enrolled72ConditionsStimulant Use, Stimulant-Related Disorder, Healthy
3 · Its place in the literature

Who cites it

93 citing papers in PubMed, 4 syntheses or guidelines pooled it, 205 citations in OpenAlex.

  1. Pooled it
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  4. A meta-analysis of chemokines in major depression.Progress in neuro-psychopharmacology & biological psychiatry · 2016
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33 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 1 institution in 1 country.

C D RethorstDepartment of Psychiatry, The University of Texas Southwestern Medical Center, Dallas, TX, USA.
M S Toups
T L Greer
P A Nakonezny
T J Carmody
B D Grannemann
R M Huebinger
R C Barber
M H Trivedi
The University of Texas Southwestern Medical Center · US

Funding

Treatment with Exercise Augmentation for DepressionR01MH067692 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI TRIVEDI, MADHUKAR H · 2003 to 2006
$2.3M
An Exercise Intervention to Prevent Interferon-Induced Depression in Hepatitis CK01MH097847 · NIMH · UT SOUTHWESTERN MEDICAL CENTER · PI RETHORST, CHAD D · 2013 to 2016
$595k
NIMH NIH HHS 5-R01-MH067692NIMH NIH HHS K01 MH097847NIMH NIH HHS R01 MH067692
6 · The paper itself

Abstract

Exercise is an efficacious treatment for major depressive disorder (MDD) and has independently been shown to have anti-inflammatory effects in non-depressed subjects. Patients with MDD have elevated inflammatory cytokines but it is not known if exercise affects inflammation in MDD patients and whether these changes are clinically relevant. In the TReatment with Exercise Augmentation for Depression (TREAD) study, participants who were partial responders to a selective serotonin reuptake inhibitor were randomized to receive one of two doses of exercise: 16 kilocalories per kilogram of body weight per week (KKW), or 4 KKW for 12 weeks. Blood samples were collected before initiation and again at the end of the 12-week exercise intervention. Serum was analyzed using a multiplexed ELISA for interferon-γ (IFN-γ), interleukin-1β (IL-1β), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α). Higher baseline levels of TNF-α were associated with greater decrease in depression symptoms over the 12-week exercise period (P<0.0001). In addition, a significant positive correlation between change in IL-1β and change in depression symptom scores was observed (P=0.04). There were no significant changes in mean level of any cytokine following the 12-week intervention, and no significant relationship between exercise dose and change in mean cytokine level. Results suggest that high TNF-α may differentially predict better outcomes with exercise treatment as opposed to antidepressant medications for which high TNF-α is linked to poor response. Our results also confirm findings from studies of antidepressant medications that tie decreasing IL-1β to positive depression treatment outcomes.

Indexed as

Exercise TherapyAdolescentAdultAntidepressive AgentsCombined Modality TherapyCytokinesEnzyme-Linked Immunosorbent AssayFemaleHumansInflammationInterferon-gammaInterleukin-1betaInterleukin-6Major Depressive DisorderMaleMiddle AgedAntidepressive AgentsCytokinesIFNG protein, humanIL6 protein, humanInterferon-gammaInterleukin-1betaInterleukin-6Selective Serotonin Reuptake InhibitorsTumor Necrosis Factor-alpha

Identifiers

PMID22925832
PMCPMC3511631
OpenAlexW2116159412

What OpenQuestion holds

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.