ArticleJournal of affective disorders2013
A genome-wide association study of seasonal pattern mania identifies NF1A as a possible susceptibility gene for bipolar disorder.
Article in Journal of affective disorders, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Genome-wide Association Studies for Female Fertility Traits in Chinese and Nordic Holsteins.Scientific reports · 2017Pooled it
- Genotype epigenome phenotype integration reveals peripheral immune contributions to type I bipolar disorder.Nature communications · 2026Article
- Auts2 enhances neurogenesis and promotes expansion of the cerebral cortex.Journal of advanced research · 2025Article
- Roles of the NFI/CTF gene family in transcription and development: update 2025.Academia biology · 2025Article
- Significant phenotypic variability in a multigenerational family with anClinical case reports · 2024Article
- Genetic contributions to bipolar disorder: current status and future directions.Psychological medicine · 2021Review
- Erotomania and phenotypic continuum in a family frameshift variant of AUTS2: a case report and review.BMC psychiatry · 2021Review
- Article
- MicroRNA Alterations in Induced Pluripotent Stem Cell-Derived Neurons from Bipolar Disorder Patients: Pathways Involved in Neuronal Differentiation, Axon Guidance, and Plasticity.Stem cells and development · 2020Article
- Genetic Intersections of Language and Neuropsychiatric Conditions.Current psychiatry reports · 2020Review
- PGM5 is a promising biomarker and may predict the prognosis of colorectal cancer patients.Cancer cell international · 2019Article
- Mice with reduced DAT levels recreate seasonal-induced switching between states in bipolar disorder.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2018Article
- Mixed States in Bipolar Disorder: Etiology, Pathogenesis and Treatment.Chonnam medical journal · 2017Review
- Replication of genome-wide association study (GWAS) susceptibility loci in a Latino bipolar disorder cohort.Bipolar disorders · 2016Article
- Reciprocal autoregulation by NFI occupancy and ETV1 promotes the developmental expression of dendrite-synapse genes in cerebellar granule neurons.Molecular biology of the cell · 2016Article
- Glutamatergic and HPA-axis pathway genes in bipolar disorder comorbid with alcohol- and substance use disorders.Metabolic brain disease · 2016Article
- Investigating the mechanism(s) underlying switching between states in bipolar disorder.European journal of pharmacology · 2015Review
- Genetic association study of circadian genes with seasonal pattern in bipolar disorders.Scientific reports · 2015Article
- Genome-wide distribution of Auts2 binding localizes with active neurodevelopmental genes.Translational psychiatry · 2014Article
- The role of AUTS2 in neurodevelopment and human evolution.Trends in genetics : TIG · 2013Review
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveThe use of subphenotypes may be an effective approach for genetic studies of complex diseases. Manic episodes with a seasonal pattern may distinguish phenotypic subgroups of bipolar subjects that may also differ genetically.
methodWe have performed a genome-wide association study using GAIN genotype data from the Bipolar Genome Study (BiGS) and bipolar subjects that were categorized as having either seasonal or non-seasonal patterned manic episodes.
resultsA bipolar case-only analysis identified three genomic regions that differed between seasonal and non-seasonal patterned manic episodes of bipolar subjects. The most significant association was for rs41350144, which lies within an intron of NF1A gene on 1p31 (P=3.08×10(-7), OR=2.27). Haplotype construction using flanking three SNPs (rs41453448, rs1125777, and rs12568010) spanning 7549bp showed a more significant association (P=2.12×10(-7), OR=0.4).
conclusionsThese data suggest that genetic variants in the NF1A gene region may predispose to seasonal patterned of mania in bipolar disorder.
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