Trial reportBritish journal of haematology2012
High dose vitamin D therapy for chronic pain in children and adolescents with sickle cell disease: results of a randomized double blind pilot study.
Trial report in British journal of haematology, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 36 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Pilot Study of Vitamin D to Ameliorate Chronic Pain in Sickle Cell Disease
Weekly Vitamin D3 for Treatment of Hypovitaminosis D in Children and Adolescents With Inflammatory Bowel Disease
Who cites it
36 citing papers in PubMed, 6 syntheses or guidelines pooled it, 73 citations in OpenAlex.
- Vitamin D supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2020Pooled it
- Interventions for treating neuropathic pain in people with sickle cell disease.The Cochrane database of systematic reviews · 2019Pooled it
- Vitamin D supplementation for sickle cell disease.The Cochrane database of systematic reviews · 2017Pooled it
- Vitamin D for the treatment of chronic painful conditions in adults.The Cochrane database of systematic reviews · 2015Pooled it
- Pooled it
- Analgesic management of uncomplicated acute sickle-cell pain crisis in pediatrics: a systematic review and meta-analysis.Jornal de pediatriaPooled it
- Safety and efficacy of monthly high-dose vitamin DEuropean journal of pediatrics · 2024Trial
- Safety and Efficacy of High-dose Daily Vitamin D3 Supplementation in Children and Young Adults With Sickle Cell Disease.Journal of pediatric hematology/oncology · 2015Trial
- The effect of a single, large bolus of vitamin D in healthy adults over the winter and following year: a randomized, double-blind, placebo-controlled trial.European journal of clinical nutrition · 2015Trial
- Vitamin D Deficiency as a Potential Modifier of Hematological Outcomes and Vaso-Occlusive Crisis Frequency in Sickle Cell Disease: Evidence from a Sudanese Cohort.Biomedicines · 2026Article
- Vitamin D deficiency in sickle cell disease: a neglected comorbidity in Tunisia.Annals of hematology · 2026Article
- Article
- Clinical Vignettes, Part II: Eyes, Teeth, and Bone.Hematology/oncology clinics of North America · 2022Review
- Review
- Femur Fracture in a Premature Infant: An Unusual Association of Sickle Cell Disease with Osteogenesis Imperfecta.The American journal of case reports · 2020Article
- American Society of Hematology 2020 guidelines for sickle cell disease: management of acute and chronic pain.Blood advances · 2020Article
- Vitamin D supplementation and pain-related emergency department visits in children with sickle cell disease.Complementary therapies in medicine · 2020Article
- Current and novel therapies for the prevention of vaso-occlusive crisis in sickle cell disease.Therapeutic advances in hematology · 2020Review
- Vitamin D and Its Potential Interplay With Pain Signaling Pathways.Frontiers in immunology · 2020Review
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
13 authors at 4 institutions in 1 country.
Funding
Abstract
We report results of a pilot study of high-dose vitamin D in sickle cell disease (SCD). Subjects were given a 6-week course of oral high-dose cholecalciferol (4000-100 000 IU per week) or placebo and monitored prospectively for a period of six months. Vitamin D insufficiency and deficiency was present at baseline in 82·5% and 52·5% of subjects, respectively. Subjects who received high-dose vitamin D achieved higher serum 25-hydroxyvitamin D, experienced fewer pain days per week, and had higher physical activity quality-of-life scores. These findings suggest a potential benefit of vitamin D in reducing the number of pain days in SCD. Larger prospective studies with longer duration are needed to confirm these effects.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.