ReviewFuture medicinal chemistry2012
Modulating macroautophagy: a neuronal perspective.
Review in Future medicinal chemistry, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed.
- Correlation of autophagy and Alzheimer's disease with special emphasis on the role of phosphodiesterase-4.3 Biotech · 2025Review
- Autophagy Function and Benefits of Autophagy Induction in Models of Spinocerebellar Ataxia Type 3.Cells · 2023Article
- Tau Abnormalities and Autophagic Defects in Neurodegenerative Disorders; A Feed-forward Cycle.Galen medical journal · 2020Review
- Autophagy Modulation as a Treatment of Amyloid Diseases.Molecules (Basel, Switzerland) · 2019Review
- A role for autophagy in Huntington's disease.Neurobiology of disease · 2019Review
- Rare variants in the neuronal ceroid lipofuscinosis gene MFSD8 are candidate risk factors for frontotemporal dementia.Acta neuropathologica · 2019Article
- Impaired Autophagy in Motor Neurons: A Final Common Mechanism of Injury and Death.Physiology (Bethesda, Md.) · 2018Review
- Resveratrol as a Natural Autophagy Regulator for Prevention and Treatment of Alzheimer's Disease.Nutrients · 2017Review
- Autophagy in the presynaptic compartment in health and disease.The Journal of cell biology · 2017Review
- Cyclodextrin has conflicting actions on autophagy flux in vivo in brains of normal and Alzheimer model mice.Human molecular genetics · 2017Article
- mTOR independent regulation of macroautophagy by Leucine Rich Repeat Kinase 2 via Beclin-1.Scientific reports · 2016Article
- Distinguishing aggregate formation and aggregate clearance using cell-based assays.Journal of cell science · 2016Article
- Defective autophagy through epg5 mutation results in failure to reduce germ plasm and mitochondria.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2015Article
- Degradation of misfolded proteins in neurodegenerative diseases: therapeutic targets and strategies.Experimental & molecular medicine · 2015Review
- Aberrant autophagy and parkinsonism: does correction rescue from disease progression?Molecular neurobiology · 2015Review
- Nucleofection of rat pheochromocytoma PC-12 cells with human mutated beta-amyloid precursor protein gene (APP-sw) leads to reduced viability, autophagy-like process, and increased expression and secretion of beta amyloid.BioMed research international · 2015Article
- The role of autophagy in neurodegenerative disease.Nature medicine · 2013Review
Corrections and comments
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Authors and funding
3 authors.
Funding
Abstract
Over this past decade, macroautophagy has gained prominence in the field of adult-onset neurodegeneration: from sporadic disorders such as Alzheimer's and Parkinson's disease, to genetic disorders such as Huntington's disease and frontotemporal dementia, the influence of this fundamental pathway has become an important topic of discussion. While there has been particular emphasis on the potential benefits of macroautophagy, there is growing literature that also suggests that macroautophagy contributes towards neurotoxicity. In this review, we discuss the molecular mechanism of macroautophagy and the currently available pharmacological tools, with special emphasis on mammalian macroautophagy in adult brain. Studies indicate that neuronal context strongly influences the role macroautophagy plays in maintaining cellular health, reflecting an ongoing need for better understanding of how macroautophagic regulation is achieved in the heavily differentiated and polarized neurons if we are to effectively manipulate it to treat neurodegenerative disease.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.