Trial reportHealth psychology : official journal of the Division of Health Psychology, American Psychological Association2013
Longitudinal relationships between fatigue and depression in cancer patients with depression and/or pain.
Trial report in Health psychology : official journal of the Division of Health Psychology, American Psychological Association, 2013. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 37 citations in OpenAlex.
- Development and validation of a machine learning-based risk prediction model for cancer-related fatigue in ovarian cancer patients.Frontiers in oncology · 2026Article
- Mediating Role of Self-Efficacy in the Association Between Fatigue and Depressive Symptoms in Females with Rheumatoid Arthritis.Medicina (Kaunas, Lithuania) · 2025Article
- Afraid and tired: A longitudinal study of the relationship between cancer-related fatigue and fear of cancer recurrence in long-term cancer survivors.Cancer medicine · 2024Article
- Potential mechanisms of the fatigue-reducing effect of cognitive-behavioral therapy in cancer survivors: Three randomized controlled trials.Psycho-oncology · 2021Article
- Relationship Between Cancer Related Fatigue, Physical Activity Related Health Competence, and Leisure Time Physical Activity in Cancer Patients and Survivors.Frontiers in sports and active living · 2021Article
- The mediating effect of activity restriction on the relationship between perceived physical symptoms and depression in cancer survivors.Psycho-oncology · 2020Article
- Longitudinal associations between smoking and affect among cancer patients using varenicline to quit smoking.Addictive behaviors · 2019Article
- Morbidity and associated factors of depressive disorder in patients with lung cancer.Cancer management and research · 2019Article
- Distinct Evening Fatigue Profiles in Oncology Outpatients Receiving Chemotherapy.Fatigue : biomedicine, health & behavior · 2017Article
- Risk factors for depression and fatigue among survivors of hematopoietic cell transplantation.Cancer · 2016Article
- Cancer-related fatigue and associated disability in post-treatment cancer survivors.Journal of cancer survivorship : research and practice · 2016Article
- Understanding the Association of Fatigue With Other Symptoms of Fibromyalgia: Development of a Cluster Model.Arthritis care & research · 2016Observational
- Trajectories of Evening Fatigue in Oncology Outpatients Receiving Chemotherapy.Journal of pain and symptom management · 2015Article
- A longitudinal study of depression, fatigue, and sleep disturbances as a symptom cluster in women with breast cancer.Journal of pain and symptom management · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
objectiveFatigue is one of the most common and debilitating symptoms reported by cancer patients, yet relatively little is understood about its etiology. Recently, as researchers have begun to focus attention on cancer-related fatigue (CRF), depression has emerged as its strongest correlate. Few longitudinal studies, however, have examined directionality of the relationship between the two symptoms. Our aim was to evaluate the directionality of the association between depression and CRF.
methodThe study used a single-group cohort design of longitudinal data (N = 329) from a randomized controlled trial of an intervention for pain and depression in a heterogeneous sample of cancer patients. Participants met criteria for clinically significant pain and/or depression. Our hypothesis that depression would predict change in fatigue over 3 months was tested using latent variable cross-lagged panel analysis.
resultsDepressive symptoms and fatigue were strongly correlated in the sample (baseline correlation of latent variables = 0.71). Although the model showed good fit to the data, χ(2) (66, N = 329) = 88.16, p = .04, SRMR = 0.030, RMSEA = 0.032, and CFI = 1.00, neither structural path linking depression and fatigue was significant, suggesting neither symptom preceded and predicted the other.
conclusionsOur findings did not support hypotheses regarding the directionality of the relationship between depressive symptoms and fatigue. The clinical implication is that depression-specific treatments may not be sufficient to treat CRF and that instead, interventions specifically targeting fatigue are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.