ArticleEvidence-based complementary and alternative medicine : eCAM2012
In vitro and in vivo toxicity of garcinia or hydroxycitric Acid: a review.
Article in Evidence-based complementary and alternative medicine : eCAM, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
26 citing papers in PubMed, 59 citations in OpenAlex.
- IQP-GC-101 reduces body weight and body fat mass: a randomized, double-blind, placebo-controlled study.Phytotherapy research : PTR · 2014Trial
- Review
- Development of Oral In Situ Gelling Liquid Formulations of Garcinia Extract for Treating Obesity.Gels (Basel, Switzerland) · 2023Article
- Fatty acid metabolism reprogramming in ccRCC: mechanisms and potential targets.Nature reviews. Urology · 2023Review
- Article
- Hypoglycemic and hypolipidemic effects of Garcinia cambogia extracts in streptozotocin-nicotinamide induced diabetic rat model.International journal of clinical and experimental pathology · 2022Article
- Protective effect of standardised fruit extract ofAnnals of medicine · 2021Article
- Risks Associated with the Use of Garcinia as a Nutritional Complement to Lose Weight.Nutrients · 2021Review
- In S. cerevisiae hydroxycitric acid antagonizes chronological aging and apoptosis regardless of citrate lyase.Apoptosis : an international journal on programmed cell death · 2020Article
- Acute Severe Liver Injury Related to Long-TermACG case reports journal · 2020Article
- The methanolic extract of Garcinia atroviridis (MeGa) reduces body weight and food intake, and improves lipid profiles by altering the lipid metabolism: a rat model.Turkish journal of biology = Turk biyoloji dergisi · 2020Article
- Hydroxycitrate: a potential new therapy for calcium urolithiasis.Urolithiasis · 2019Review
- Weight-loss supplementation and acute liver failure: the case of Garcinia Cambogia.Internal and emergency medicine · 2018Article
- Selected Physiological Effects of aNutrients · 2018Article
- Hepatotoxicity Associated with Use of the Weight Loss SupplementCase reports in hepatology · 2018Article
- Enzyme-treated Ecklonia cava extract inhibits adipogenesis through the downregulation of C/EBPα in 3T3-L1 adipocytes.International journal of molecular medicine · 2017Article
- Suppression of fat deposition in broiler chickens by (-)-hydroxycitric acid supplementation: A proteomics perspective.Scientific reports · 2016Article
- Caloric Restriction Mimetics Enhance Anticancer Immunosurveillance.Cancer cell · 2016Article
- Anti-obesity effect of extract from fermented Curcuma longa L. through regulation of adipogenesis and lipolysis pathway in high-fat diet-induced obese rats.Food & nutrition research · 2016Article
- Gambogic acid inhibits growth, induces apoptosis, and overcomes drug resistance in human colorectal cancer cells.International journal of oncology · 2015Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Obesity is one of the pandemic chronic diseases commonly associated with health disorders such as heart attack, high blood pressure, diabetes or even cancer. Among the current natural products for obesity and weight control, Garcinia or more specifically hydroxycitric acid (HCA) extracted from Garcinia has been widely used. The evaluation of the potential toxicity of weight control supplement is of the utmost importance as it requires long term continuous consumption in order to maintain its effects. Majority of reports demonstrated the efficacy of Garcinia/HCA without any toxicity found. However, a few clinical toxicity reports on weight-loss diet supplements of which some were combinations that included Garcinia/HCA as an active ingredient showed potential toxicity towards spermatogenesis. Nonetheless, it cannot be concluded that Garcinia/HCA is unsafe. Those products which have been reported to possess adverse effects are either polyherbal or multi-component in nature. To date, there is no case study or report showing the direct adverse effect of HCA. The structure, mechanism of action, long history of the use of Garcinia/HCA and comprehensive scientific evidence had shown "no observed adverse effect level (NOAEL)" at levels up to 2800 mg/day, suggesting its safety for use.
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.