ArticleTheScientificWorldJournal2012
Expression of the type VI secretion system 1 component Hcp1 is indirectly repressed by OpaR in Vibrio parahaemolyticus.
Article in TheScientificWorldJournal, 2012. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- The multifunctional type VI secretion system ofApplied and environmental microbiology · 2025Review
- Quorum sensing regulates virulence factors in the coral pathogenApplied and environmental microbiology · 2025Article
- TssL2 of T6SS2 is required for mobility, biofilm formation, wrinkly phenotype formation, and virulence of Vibrio parahaemolyticus SH112.Applied microbiology and biotechnology · 2024Article
- IcmF2 of the type VI secretion system 2 plays a role in biofilm formation of Vibrio parahaemolyticus.Archives of microbiology · 2024Article
- Insights into virulence: structure classification of themSystems · 2023Article
- CqsA/LuxS-HapR Quorum sensing circuit modulates type VI secretion system VflT6SS2 inEmerging microbes & infections · 2021Article
- Article
- Transcriptional Regulation of the Type VI Secretion System 1 Genes by Quorum Sensing and ToxR inFrontiers in microbiology · 2017Article
- Changes in global gene expression of Vibrio parahaemolyticus induced by cold- and heat-stress.BMC microbiology · 2015Article
- Bacterial Secretome Analysis in Hunt for Novel Bacteriocins with Ability to ControlIranian journal of biotechnology · 2015Article
- H-NS regulates the Vibrio parahaemolyticus type VI secretion system 1.Microbiology (Reading, England) · 2014Article
- Article
- Dual expression profile of type VI secretion system immunity genes protects pandemic Vibrio cholerae.PLoS pathogens · 2013Article
- Cell density- and quorum sensing-dependent expression of type VI secretion system 2 in Vibrio parahaemolyticus.PloS one · 2013Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The type VI secretion system (T6SS) is bacterial protein injection machinery with roles in virulence, symbiosis, interbacterial interaction, antipathogenesis, and environmental stress responses. There are two T6SS loci, T6SS1 and T6SS2, in the two chromosomes of Vibrio parahaemolyticus, respectively. This work disclosed that the master quorum sensing (QS) regulator OpaR repressed the transcription of hcp1 encoding the structural component Hcp1 of T6SS1 in V. parahaemolyticus, indicating that QS had a negative regulatory action on T6SS1. A single σ(54)-dependent promoter was transcribed for hcp1 in V. parahaemolyticus, and its activity was repressed by the OpaR regulator. Since the OpaR protein could not bind to the upstream region of hcp1, OpaR would repress the transcription of hcp1 in an indirect manner.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.